■ Contact Dermatitis: Cell-mediated, delayed type IV immunologic reaction
■ Atopic Dermatitis: Results from a complex interaction between immunologic, genetic, environmental, and pharmacologic factors.
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Synonym: Bloch-Sulzberger's disease. Clinical Presentation (Fig. 8):
■ Appears in female neonates during the first weeks
■ Distinctive vesicular eruption that follows the lines of Blaschko
■ Vesicular phase replaced by verrucous lesions after several weeks to months
■ Spongiosis with numerous intraepidermal eosinophils
■ Intraepidermal microvesicles containing eosinophils
■ Dyskeratotic keratinocytes (may be extensive)
■ Superficial perivascular infiltrate of eosinophils
Differential Diagnosis of Eosinophilic Spongiosis:
■ Genodermatoses caused by a mutation on the X chromosome, that is, localized to Xq28; lethal in males.
1. Phan TA, Wargon O, Turner AM. Incontinentia pigmenti case series: clinical spectrum of incontinentia pigmenti in 53 female patients and their relatives. Clin Exp Dermatol 2005; 30:474-480. Erratum in: Clin Exp Dermatol 2005; 30:618.
2. Hadi-Rabia S, Froievaux S, Bodak N, et al. Clinical study of 40 cases of incontinentia pigmenti. Arch Dermatol 2003; 139:1163-1170.
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