Persistent Pigmented Purpuric

Drug Eruption


Perivascular or lichenoid infiltrate

Eosinophils in the infiltrate

Vacuolar alteration and necrotic keratinocytes often

No changes of collagen

Perivascular and interstitial, sometimes lichenoid, infiltrate

Lymphocytes, erythrocytes, and siderophages

No changes in the epidermis or slight spongiosis

Wiry bundles of collagen


■ Erythema infectiosum is caused by parvovirus B19, roseola is caused by human herpesvirus 6, and other exanthems are caused by other specific viruses.


1. Ackerman AB, Boer A, Bennin B, Gottlieb GJ. Histologic Diagnosis of Inflammatory Skin Diseases. 3rd ed. New York: Ardor Scribendi, 2005.

Was this article helpful?

0 0

Post a comment