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Specific diagnosis or differential

Table 2 Neoplasms: Benign vs. Malignant

Benign

Malignant

Small

Large

Symmetric

Asymmetric

Well circumscribed

Poorly circumscribed

Smooth margins

Irregular, jagged margins

V-shaped lesions

Not V-shaped lesions

Superficial

Deep

Not usually ulcerated

Tends to ulcerate

Neoplastic cells discretely arranged

Neoplastic cells in sheets

Aggregations uniform in size and shape

Aggregations vary in size and shape

Cells well differentiated

Cells poorly differentiated

Adnexal structures usually preserved

Adnexal structures often absent

Maturation: nuclei of cells at base of lesion smaller than those near the surface

No maturation

No necrosis or necrosis only of single cells

Necrotic cells in aggregate

No neoplastic cells in perineural locations

Neoplastic cells in perineural locations

No neoplastic cells in vessels

Neoplastic cells in vessels

Epithelial cells not in single file between collagen bundles

Epithelial cells in single file between collagen bundles

Peripheral fibrous tissue well-packed

Peripheral fibrous tissue not well-packed

Clefts between well-packed fibrous tissue and normal fibrous tissue

Clefts between neoplastic cells and altered stroma

Source: From Ref. 1.

Source: From Ref. 1.

Table 3 Patterns of Inflammatory Diseases

Ackerman's Original Nine Basic Patterns of Inflammatory Diseases Circa 1978

Table 3 Patterns of Inflammatory Diseases

Ackerman's Original Nine Basic Patterns of Inflammatory Diseases Circa 1978

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