Info

DIF: negative

DIF: negative

DIF: Intercellular deposition of IgA

DIF: negative

Abbreviations: DIF, direct immunofluorescence; PAS, periodic acid schiff.

Abbreviations: DIF, direct immunofluorescence; PAS, periodic acid schiff.

Table 3 Differential Diagnosis: Subcorneal Pustular Dermatosis

Histology (Fig. 4B):

■ Subcorneal pustule

■ Adjacent epidermis may be spongiotic

■ Superficial perivascular mononuclear cell infiltrate

Differential Diagnosis:

See Table 3.

Pathophysiology:

■ Etiology and pathogenesis remain unknown. References:

1. Wilkerson A, Smoller B. The pustular disorders. Semin Cutan Med Surg 2004; 23:29-38.

2. Bonifati C, Trento E, Cordiali Fei P, Muscardin L, Amantea A, Carducci M. Early but not lasting improvement of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease) after infliximab therapy: relationships with variations in cytokine levels in suction blister fluids. Clin Exp Dermatol 2005; 30:662-665.

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