Clinicopathologic Correlation:

Clinical Feature

Histopathologic Feature


Disruption of basal cells

Differential Diagnosis:

■ Other forms of EB; distinction is made based on clinical presentation, immunofluorescence mapping on salt-spit skin, and electron microscopic findings.


Autosomal dominant inheritance; EBS (Koebner) is a disease in which keratin gene mutations cause the production of defective intermediate filaments, which lead to epidermal basal cell fragility and subsequent blistering.


1. Petronius D, Bergman R, Ben Izhak O, Leiba R, Sprecher E. A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa. Am J Dermatopathol 2003; 25:198-203.

Figure 3 (A) Impetigo (clinical). (B) Dermatophytosls (clinical). (C) Impetigo; candidiasis; dermatophytosis (histological).
Figure 4 (A) Subcorneal pustular dermatosis (clinical). (B) Subcorneal pustular dermatosis (histological).

Figure B Benign familial pemphigus (clinical and histological).

Figure B Benign familial pemphigus (clinical and histological).

Figure 11 Transient acantholytic dermatosis (clinical and histological).
Figure 12 (A) Epidermolysis bullosa simplex (clinical). (B) Epidermolysis bullosa simplex (histological).

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