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Clinicopathologic Correlation:

Clinical Feature

Histopathologic Feature

Vesicles

Disruption of basal cells

Differential Diagnosis:

■ Other forms of EB; distinction is made based on clinical presentation, immunofluorescence mapping on salt-spit skin, and electron microscopic findings.

Pathophysiology:

Autosomal dominant inheritance; EBS (Koebner) is a disease in which keratin gene mutations cause the production of defective intermediate filaments, which lead to epidermal basal cell fragility and subsequent blistering.

Reference:

1. Petronius D, Bergman R, Ben Izhak O, Leiba R, Sprecher E. A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa. Am J Dermatopathol 2003; 25:198-203.

Figure 3 (A) Impetigo (clinical). (B) Dermatophytosls (clinical). (C) Impetigo; candidiasis; dermatophytosis (histological).
Figure 4 (A) Subcorneal pustular dermatosis (clinical). (B) Subcorneal pustular dermatosis (histological).

Figure B Benign familial pemphigus (clinical and histological).

Figure B Benign familial pemphigus (clinical and histological).

(A)
Figure 11 Transient acantholytic dermatosis (clinical and histological).
Figure 12 (A) Epidermolysis bullosa simplex (clinical). (B) Epidermolysis bullosa simplex (histological).

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