Info

ment of the interstitium

nuclei

Edema of the papil-

No edema of the papil-

No edema of the

lary dermis

lary dermis

papillary dermis

Spongiosis

No changes in the

No changes in the

epidermis epidermis epidermis epidermis

Pathophysiology:

■ Lupus erythematosus is considered to be an autoimmune disease but the mechanism precisely is not known; genetic factors, estrogens, and deficiency of complement also seem to play a role in the pathogenesis.

■ ANA and anti-ds DNA antibodies are variably present in the serum of patients with tumid lupus erythematosus, and direct immunofluorescence is usually negative.

References:

1. Kuhn A, Sonntag M, Ruzicka T, et al. Histopathologic findings in lupus erythematosus tumidus: review of 80 patients. J Am Acad Dermatol 2003; 48:901-908.

2. Lee SS, Ackerman AB. Lupus dermatitis is an expression of systemic lupus erythematosus. Dermatopathol: Prac & Conc 1997; 3:346-347.

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