ment of the interstitium


Edema of the papil-

No edema of the papil-

No edema of the

lary dermis

lary dermis

papillary dermis


No changes in the

No changes in the

epidermis epidermis epidermis epidermis


■ Lupus erythematosus is considered to be an autoimmune disease but the mechanism precisely is not known; genetic factors, estrogens, and deficiency of complement also seem to play a role in the pathogenesis.

■ ANA and anti-ds DNA antibodies are variably present in the serum of patients with tumid lupus erythematosus, and direct immunofluorescence is usually negative.


1. Kuhn A, Sonntag M, Ruzicka T, et al. Histopathologic findings in lupus erythematosus tumidus: review of 80 patients. J Am Acad Dermatol 2003; 48:901-908.

2. Lee SS, Ackerman AB. Lupus dermatitis is an expression of systemic lupus erythematosus. Dermatopathol: Prac & Conc 1997; 3:346-347.

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