Areas of epidermal necrosis

Small vesicles

Inflammation localized to papillary tips

Classification Variants, Mutations, and Other:

■ HLA A1/B8/DR3, DQ2 common (95-100%) in dermatitis herpetiformis

■ Increased incidence of GI lymphoma and non Hodgkin lymphoma

■ Hypochlorohydria and atrophic gastritis (antiparietal cell antibodies); pernicious anemia associations

■ Other associations: thyroid disease (thyroid microsomal antibodies) and other autoimmune diseases (dermato-myositis, myasthenia gravis, rheumatoid arthritis, and lupus erythematosus)

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