Immunologic Criteria and Location of Bulla Formation Autoimmune vs. Nonimmunologic Etiology

■ Autoimmune

■ Nonimmunologic

Composition of the Inflammatory Infiltrates and Other

Histologic Features Immunofluorescence Patterns and Molecular Studies

SUBEPIDERMAL VESICULOBULLOUS DISORDERS Bullous Pemphigoid Pemphigoid Gestationis

Mucous Membrane Pemphigoid/Cicatricial Pemphigoid Dermatitis Herpetiformis

Linear IgA Bullous Disease and Chronic Bullous Disease of Childhood Bullous Lupus Erythematosus Epidermolysis Bullosa Acquisita Junctional Epidermolysis Bullosa

Dystrophic Epidermolysis Bullosa (Autosomal Dominant and Recessive) Porphyria and Pseudoporphyria Bullous Drug Eruption the split between epidermis and dermis and the character of the vesicle or bulla, clinically. These disorders are:

■ Bullous pemphigoid (BP)

■ Pemphigoid gestationis (PG)

■ Mucous membrane pemphigoid (MMP)/cicatricial pemphigoid (CP)

■ Dermatitis herpetiformis (DH)

■ Linear IgA bullous disease (LABD)

■ Chronic bullous disease of childhood (CBDC)

■ Bullous lupus erythematosus (BLE)

■ Epidermolysis bullosa acquisita (EBA) Characterization of the antigenic molecules of the basement membrane zone in these disorders using patient sera has allowed investigators to generate an elegant diagram of the epidermal and mucosal basement membrane molecular structure (Fig. 1).

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