Bullous Drug Eruption

Bullous pemphigoid Pemphigoid gestationis Mucous membrane pemphigoid

Linear IgA bullous dermatosis Salt Split Skin ^^ Separation ^^ Anchoring filaments

Linear IgA bullous dermatosis

Epidermolysis bullosa acquisita Bullous lupus erythematosus yK y—rrr

Bullous pemphigoid Pemphigoid gestationis Mucous membrane pemphigoid

Linear IgA bullous dermatosis Salt Split Skin ^^ Separation ^^ Anchoring filaments

Linear IgA bullous dermatosis

Epidermolysis bullosa acquisita Bullous lupus erythematosus

, Anchoring plaque °

Figure 1 Schematic of the basement membrane zone antigens recognized by autoantibodies in the immune-mediated subepidermal vesiculobullous disorders. Salt split skin separation occurs in the lamina lucida, where anchoring filaments are found. Hemidesmosomes are the target antigens in bullous pemphigoid, pemphigoid gestationis, and mucous membrane pemphigoid. Mucous membrane pemphigoid is heterogeneous with most individuals having immunoreactants on the epidermal side of the blister while occasional patients have immunoreactants on the dermal side of the blister. Linear IgA bullous disease antibodies are complex and bind a variety of antigens above and below the lamina lucida. Collagen VII/anchoring fibrils are the target antigens of epidermolysis bullosa acquisita and bullous lupus erythematosus.

Direct Immunofluorescence (DIF)

1 Patient's skin

1 Patient's skin

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