Antigens

■ The noncollagenous domains (NC1 and NC2) of collagen VII—a component of anchoring fibrils

Pathophysiology:

Antibodies to collagen may destabilize collagen fibers, and combined with trauma could contribute to blistering.

Clinicopathologic Correlation:

Clinical Feature

Pathologic Feature

Scarring vs. nonscarring

Different antigens

variants

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