Ladinin (LAD-1, now known to be an epitope of BPAg2).

Some patients have antibodies to collagen VII.


Antibody deposits lead to complement activation and neutrophil accumulation at the basement membrane zone.

Release of proteases by neutrophils and degradation of basement membrane proteins produces blister.

Clinicopathologic Correlation :

Clinical Feature

Pathologic Feature

Vesicles and bullae on polycyclic

Neutrophils at the DEJ


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