Our knowledge of CD137 in the regulation of innate immunity is rudimentary. CD137 and its ligand are expressed on a wide variety of cell types in both transmembrane and soluble forms. Signaling through CD137 pathway is capable of activating DC, NK and T cells. Therefore, CD137 pathway may provide a critical link between innate and adaptive immunity. Understanding the mechanisms underlying the regulation of CD137 pathway in innate immunity may lead to the development of new and improved forms of immunotherapy for a broad spectrum of disease states, including the prevention and therapy of autoimmunity, graft rejection, and stimulation of tumor-specific immune response.

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