CD137/CD137L pathway is involved in the generation of a fully competent T cell response (Blazar et al., 2001; DeBenedette et al., 1999; Tan et al., 1999, 2000). Absence of CD137/CD137L interactions prevent the development of certain autoimmune diseases (Seo et al., 2003, 2004). Elevated serum levels of soluble forms of receptor and ligand were detected in patients with various autoimmune diseases (Jung et al., 2004; Michel et al., 1998; Sharief, 2002). These studies suggest CD137/CD137L interactions may play a role in the pathogenesis of autoimmune disease.
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