Abbas, A.K., Lichtman, A.H., and Pober, J.S. (1997). Cellular and Molecular Immunology. W.B. Saunders, Philadelphia, Pennsylvania.

Adi, S., Wu, N.-Y., and Rosenthal, S.M. (2001). Growth factor-stimulated phosphorylation of Akt and p70S6K is differentially inhibited by LY294002 and wortmannin. Endocrinology, 142, 498-501.

Appleman, L.J., van Puijenbroek, A.A. F.L., Shu, K.M., Nadler, L.M., and Boussiotis, VA. (2002). CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activating of the PI3K/PKB signaling pathway in primary human T cells. J. Immunol., 168, 2729-2736.

Arch, R.H., and Thompson, C.B. (1998). 4-1BB and 0x40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kB. Mol. Cell. Biol., 18, 558-565.

Beginat, J., Sallusto, F., and Lanzavecchia, A. (2003). Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells. Pathologie Biologie., 51, 64-66.

Bertram, E.M., Lau, P., and Watts, T.W. (2002). Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J. Immunol., 168, 3777-3785.

Botz, J., Zerfass-Thome, K., Spitzovsky, D., Delius, H., Vogt, B., Eilers, M., Hatzigeorgiou, A., and Jansen-Durr, P. (1996). Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter. Mol. Cell. Biol., 16, 3401-3409.

Brennan, P., Babbage, J.W., Burgering, B.M.T., Groner, B., Reif, K., and Cantrell, D.A. (1997). Phos-phatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity, 7, 679-689.

Brown, T.J., Emswiler, J., Raecho, H., Larsen, C.P., Pearson, T.C., Ledbetter, J.A., Aruffo, A., and Mittler. R.S. (1997). 4-1BB costimulatory signals preferentially induce CD8 T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med., 186, 47-55.

Burr, J.S., Savage, N.D., Messah, G.E., Kimzey, S.L., Shaw, A.S., Arch, R.H., and Green, J.M. (2001). Cutting edge: Distinct motifs within CD28 regulate T cell proliferation and induction of Bc1-Xl. J. Immunol., 166, 5331-5335.

Cannons, J.L., Choi, Y., and Watts, T.H. (2000). Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response. J. Immunol., 165, 6193-6204.

Carreno, B.M., and Collins, M. (2002). The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol., 20, 29-53.

Chalupny, N.J., Peach, R., Hollenbaugh, D., Ledbetter, J.A., Farr, A.G., and Aaruffo, A. (1992). T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proc. Natl. Acad. Sci. USA., 89, 10360-10364.

Chambers, C.A., and Allison, J.P. (1999). Costimulatory regulation of T cell function. Curr. Opin. Cell. Biol., 11, 203-210.

Chan, F.K.-M., Siegel R.M., and Lenardo, M.J. (2000). Signaling by the TNF receptor superfamily and T cell homeostasis. Immunity, 13, 419-422.

Choi, B.K., Bae, J.S., Choi, E.M., Kang, W.J., Sakaguchi, S., Vinay, D.S., and Kwon, B.S. (2004). 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cell. J. Leukoc Biol., 75, 785-791.

Futagawa, T., Akiba, H., Kodama, T., Takeda, K., Hosoda, Y., and Yagita, H. (2002). Expression and function of 4-1BB and 4-1BB ligand on murine dendrine dendritic cells. Int. Immunol., 14, 275-286.

Gingras, A.-C., Raught, B., and Sonenberg, N. (2001). Regulation of translation initiation by FRAP/mTOR. Genes Dev., 15, 807-826.

Gravestein, L.A., Amsen, D., Boes, M., Calvo, C.R., Kruisbeek, A.M., and Borst, J. (1998). The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. Eur. J. Immunol., 28, 2208-2216.

Gravestein, L.A., and Borst, J. (1998). Tumor necrosis factor receptor family members in the immune system. Semin. Immunol., 10, 423-434.

Grillot, D.A., Merino, R., and Nunez, G. (1995). Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J. Exp. Med., 182, 1973-1983.

Jang, I.K., Lee, Z.H., Kim, Y.-J., and Kwon. B.S. (1998). Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kB. Biophys. Biochem. Res. Commun., 242, 613621.

Jones, R., Parsons, G.M., Bonnard, M., Chan, VS.F., Yeh, W.-C., Woodgett, J.R., and Ohashi, P.S. (2000). Protein kinase B regulates T lymphocyte survival, nuclear factor kB activation, and Bc1-Xl levels in vivo. J. Exp. Med. 191, 1721-1734.

June, C.H., Ledbetter, J.A., Linsley, P.S., and Thompson, C.B. (1990). Role of the CD28 receptor in T-cell activation. Immunol. Today, 11, 211-216.

Kanegane, H., and Tosato, G. (1996). Activation of naive and memory T cells by interleukin-15. Blood, 88, 230-235.

Kenneth, A. T., and Thompson, C. B. (2002). Activation and Inhibition of lymphocytes by costimulation. J. Clin. Invest., 109, 295-299.

Khoshnan, A., Tindell, C., Laux, I., Bae, D., Bennett, B., and Nel, A.E. (2000). The NF-kB cascade is important in Bc1-Xl expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes. J. Immunol., 165, 1743-1749.

Kim, Y.J., Brutkiewicz, R.R., and Broxmeyer, H.E. (2002). Role of 4-1BB (CD137) in the functional activation of cord blood. Blood, 100, 3253 and 3260.

Kim, Y.Z., Mantel, P.L., June, C.H., Kim, S.H., and Kwon, B.S. (1999). 4-1BB costimulation promotes human T cell adhesion to fibronectin. Cell. Immunol., 192, 13-21.

Kuo, C.J., Chung, J., Fiorentino, D.F., Flanagan, W.M., Blenis, J., and Crabtree, G.R. (1992). Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature, 358, 70-73.

Kwon, B., Lee, H.W., and Kwon, B.S. (2002). New insights into the role of 4-1BB in immune response: Beyond CD8+ T cells. Trend Immunol., 23, 378-380.

Kwon, B., Moon, C.H., Seo, S.K., and Kwon, B.S. (2000). 4-1BB: Still in the midst of darkness. Mol. Cells, 30, 119-126.

Kwon, B.S., and Weissman, S.M. (1989). cDNA sequences of two inducible T-cell genes. Proc. Natl Acad. Sci. USA, 86, 1963-1967.

Lantz, O., Grandhean, I., Matzinger, P., and Di Santo, J.P. (2000). Gamma chain required for naive CD4+ T cell survival but not for antigen proliferation. Nat. Immunol., 1, 54-58.

Lee, H.H., Dadgostar, H., Cheng, Q., Shu, J., and Cheng, G. (1999). NF-KB-mediatedup-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. Proc. Natl. Acad. Sci. USA., 96,9136-9141.

Lee, H.W., Nam, K.O., Park. S.J., and Kwon, B.S. (2003a). 4-1BB Enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D2 and E and cyclin-dependent kinase inhibitor p27kip1. Eur. J. Immunol., 33, 2133-2141.

Lee, H.W., Nam, K.O., Seo, S.K., Kim, Y.H., Kang, H., and Kwon, B.S. (2003b). 4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocytes. Cellular Immunol., 223, 143-150.

Lee, H.W., Park, S.J., Choi, B.K., Kim, H.H., Nam, K.O., and Kwon, B.S. (2002). 4-1BB promotes the survival of CD8+T lymphocytes by increasing expression of Bc1-Xl and Bfl-1. J. Immunol., 169, 4882-4888.

Lenschow, D.J., Walunas, T.L., and Bluestone, J.A. (1996). CD28/B7 system of T cell costimulation. Annu. Rev. Immunol., 14, 233-258.

Leone, G., DeGregori, J., Sears, R., Jakoi, L., and Nevins, H. (1997). Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature, 387, 422-426.

Lodolce, J.P., Boone, D.L., Chai, S., Swain, R.E., Dassopoulos, T., Trettin, S., and Ma, A. (1998). IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity, 9, 669-676.

Marwali, M.R., Rey-Ladino, J., Dreolini, L., Shaw, D., and Takei, F. (2003). Membrane cholesterol regulates LFA-1 function and lipid raft heterogeneity. Blood, 102, 215-222.

Matakeyama, M., Brill, J.A., Fink, G.R., and Weinberg, R.A. (1994). Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein. Genes Dev., 8, 1759-1771.

Melero, I., Shuford, W.W., Newby, S.A., Aruffo, A., Ledbetter, J.A., Hellstrom, K.E., Mittler, R.S., and Chen, L. (1997). Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat. Med., 3, 682-685.

Michael, C. (2003). Costimulation of T cells by 0X40, 4-1BB, and CD27. Cytokine Growth Factor Rev, 14, 265-273.

Montagnoli, A., Fiore, F., Eytan, E., Carrano, A.C., Draetta, G.F., Hershko, A., and Pagano, M., (1999). Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev., 13, 1181-1189.

Moon, J.J., and Nelson, B.H. (2001). Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor. J. Immunol., 167, 2714-2723.

Mueller, D.L. (2000). T cell: A proliferation of costimulatory molecules. Curr. Biol., 10, R227-R230.

Mueller, D.L., Jenkins, M.K., and Schwarz, R.H. (1989). Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol., 7, 445-480.

Nakajima, H., Shores, E.W., Noguchi, M., and Leonard, W.J. (1997). The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis. J. Exp. Med., 185, 189-195.

Nam, K.O., Kang, H.S., Shin, M., Cho, K.H., Kwon, B., Kwon, B.S., Kim, S.J., and Lee, H.W. (2005). Cross-linking of 4-1BB activates TCR-signaling pathways in CD8+ T lymphocytes. J. Immunol., 174, 1898-1905.

Okkenhaung, K., Wu, L., Garza, K.M., La Rose, J., Khoo, W., Odermatt, B., and Mak T.K. (2001). A point mutation in CD28 distinguishes proliferative signals from survival signals. Nat. Immunol., 2, 325-332.

Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M., and Donner, D.B. (1999). NF-kB activation by tumour necrosis factor requires the Akt serine-theonine kinase. Nature, 401, 82-85.

Pan, P.Y., Gu, P., Li, Q., Xu, D., Weber, K., and Chen, S.H. (2004). Regulation of Dendritic Cell Function by NK Cell: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation. J. Immunol., 172, 4779-4789.

Poltak, K., Kato, J.-Y., Solomon, M.J., Sherr, C.J., Massague, J., Roberts, J.M., and Koff, A. (1994). p27Kip1, a cyclin-cdk inhibitor, links transforming growth factor-b and contact inhibition to cell cycle arrest. Genes Dev. , 8, 9-22.

Resnitzky, D., and Reed, S.I. (1995). Different roles for cyclins D1 and E in regulation of the G1-to-S

transition. Mol. Cell. Biol., 15, 3463-3469. Rothstein, D.M., and Sayegh, M.H. (2003). T-cell costimulatory pathways in allograft rejection and tolerance. Immunol. Rev., 196, 85-108. Salazar, E.P, and Rozengurt, E. (1999). Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cells. J. Biol. Chem., 274,2837128378.

Samia, J.K., and Mohamed, H.S. (2004). The Roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity, 20, 529-538. Saoulli, K., Lee, S.Y., Cannons, J.L., Yeh W.C., Santana, A., Goldstein, M.D., Bangia, N., DeBenedette, M.A., Mak, T.W., Choi, Y., and Watts, T. H. (1998). CD28-independent, TRAF2-dependent cos-timulation of resting T cells by 4-1BB ligand. J. Exp. Med., 187, 1849-1862. Schluns, K.S., Kieper, W.C., Jameson, S.C., and Lefrancois, L. (2000). Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol., 1, 426-432. Schwarz, H., Tuckwell, J., and Lotz, M. (1993). A receptor-induced by lymphocyte activation (ILA): A new member of the human nerve growth factor/tumor necrosis factor receptor family. Gene, 134, 295-298.

Sherr, C.J., and Roberts, J.M. (1999). CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev., 13, 1501-1512. Seo, S.K., Choi, J.H., Kim, Y.H., Young, H., Kang, W.J., Suh, J.H., Choi, B. K., Vinay, B.S., and Kwon,

B.S. (2004). 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat. Med., 10, 1088-1094. Shuford, W.W., Klussman, K., Tritchler, D.D., Loo, D.K., Chalupny, J., Siadak, A.W., Brown, T.J.,

Emswiler, J., Raecho, H., Larsen, C.P., Pearson, T.C., Ledbetter, J.A., Aruffo, A., and Mittler, R.S. (1997). 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J. Exp. Med., 186, 46-55. Tan, J.T., Ha, J., Cho, H.R., Tucker-Burden C., Hendrix, R.C., Mittler, R.S., Pearson, T.C., and Larsen,

C.P. (2000). Analysis of expression and function of the costimulatory molecule 4-1BB in alloimmune responses. Transplantation, 70, 175-183.

Toyoshima, H., and Hunter, T. (1994). p27, a novel inhibitor of G1 cyclin/Cdk protein kinase activity, is related to p21. Cell, 78, 67-74. Tsvetkov, L.M., Yeh, K.H., Lee, S.J., Sun, H., and Zhang, H. (1999). p27 (Kip1) ubiquitination and degradation is regulated by the SCF (Skp2) complex through phosphorylated Thr187 in p27. Curr. Biol., 9, 661-664.

Unutmaz, D., Baldoni, F., and Abrignani, S. (1995). Human naïve T Cells activated by cytokines differentiate into a split phenotype with functional features intermediate between naïve and memory T cells. Int. Immunol., 7, 1417-1424. Unutmaz, D., Pileri, P., and Abrignani, S. (1994). Antigen-independent activation of naïve and memory resting T cell by a cytokine combination. J. Exp. Med., 180, 1159-1164. Van Parijs, L., and Abbas, A.K. (1998). Homeostasis and self-tolerance in the immune system: Turning lymphocytes off. Science, 280, 243-248. Vidalain, P.O., Azocar, O., Servet-Delprat, C., Rabourdin-Combe, C., Gerlier, D., and Manie, S. (2000). CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBOJ., 19, 33043313.

Vinay, D.S., andKwon, B.S. (1998). Role of4-1BB in immune response. Semin. Immunol., 10,481-489. Vlahos, C.J., Matter, W.F., Hui, K.Y., and Brown, R.F., (1994). A specific inhibitor of phosphatidylinos-itol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002/ J. Biol. Chem., 269, 5241-5248.

Watts, T.H., and DeBenedette, M.A. (1999). T cell co-stimulatory molecules other than CD28. Curr.

Opin. Immunol., 11, 286-293. Weinberg, A.D., Vella, A.T., and Croft, M. (1998). 0x-40: Life beyond the effector T cell stage. Semin. Immunol., 10, 471-480.

Wilcox, R.A., Chapoval, A.I., Gorski, K.S., Otsuji, M., Shin, T., Flies, D.B., Tamada, K., Mittler, R.S., Tsuchiya, H., Pardoll, D.M., and Chen, L. (2002). Cutting edge: Expression of functional CD137 receptor by dendritic cells. J Immunol., 168, 4262-4267.

Ye, H., Park, Y.C., Kreishman, M., Kieff, E., and Wu, H. (1999). The structure basis forthe recognition of diverse receptor sequence by TRAF2. Mol. Cell, 4, 321-330. Zhang, X., Sun, S., Hwang, I., Tough, D.F., and Sprent, J. (1998). Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity, 8, 591-599. Zheng, G., Wang, B., and Chen, A. (2004). The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cell. J. Immunol., 173, 2428-2434.

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