CD137 was first identified in screens for receptors on mouse concanavalin A-activated helper and cytotoxic T cell lines (Kwon and Weissman, 1989). CD137 (also called 4-1BB) was originally named "induced by lymphocyte activation" (ILA) in humans, and 4-1BB in the mouse (Pollok et al., 1993; Schwarz et al., 1993). It is a 30-kD glycoprotein and exists both as a monomer and a 55-kD
dimer on the T cell surface. The entire gene spans approximately 13 kb of mouse chromosome 4.
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