Here we assemble experimental data on the effect of CD137 on T cell responses. Besides as a potent costimulator for naive T cell, the CD137 pathway plays an important role on regulation of Treg cell function, memory T cell development, and prevention ofT cell tolerance. A key issue to be addressed is that the same agonistic CD137 antibody promotes or inhibits CD4+ T cell potent antitumor response whereas inhibits humoral response. Eradication of this mechanism may help delineate complicated function of CD137 signal in the regulation of T cell development; priming, contraction, maintenance, and memory.
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