Yh 1885

2,4-Diaminoquinazoline (SK&F)

Figure 7 Some K+ competitive inhibitors of the gastric H+/K+ -ATPase. SCH 28080 was the first imidazopyridine shown to competitively inhibit the ATPase, and fused-ring analogs or derivatives of SCH 28080 have been tested in humans, showing superior pH control. The quinolines or quinazolines have not reached clinical trial, although they appear effective.

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