The Role of Modified Low Density Lipoprotein Inflammatory Mediators and Reactive Oxygen Species ROS in Atherosclerosis

While the accumulation and retention of cholesterol in macrophages and other leukocytes contribute to atherosclerosis, recent studies have uncovered a number of key inflammatory mediators that participate in the activation of the endothelium. This endothelial activation leads to the recruitment and activation of both monocytes and Tcells at the site of the developing lesion.6-8 The resulting activated cells release ROS (e.g., hydrogen peroxide, hydroxyl radical,

Was this article helpful?

0 0

Post a comment