Epidemiological studies clearly indicate that low HDLc (<40mgdL_ 1) represents a significant independent risk factor for CHD. While statin therapy effectively lowered LDLc by up to 45%, statins generally produce only very modest increases in HDLc levels, usually less than 10%.34 Currently, only two alternatives are available for treating low HDLc: fibrates and niacin-based (Figure 8) therapies. Fibrates increase HDLc by ~ 10-15%, but have a more pronounced effect on TG lowering. Fibrates have been available since the early 1970s. The fibrate mechanism of action cia>o-iC CH (>o(ch2)^ C^y^j-O-,
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