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Testosterone (Table 1) is the principal androgen in human circulation. Androgens stimulate and maintain masculine sexual characteristics of the genital tract, secondary sexual characteristics, fertility, and anabolic effects of somatic tissues.1'2 Testosterone may be used clinically at physiological doses for androgen replacement therapy, but pharmacological androgen therapy is often abused. The goal of testosterone replacement therapy is to attempt to duplicate the normal physiological pattern of androgen exposure to the body.3 This is currently best accomplished with testosterone, rather than synthetic derivatives of testosterone. Thus, an understanding of the normal and pathophysiology of testosterone secretion and action is required as a basis for replacement therapy.

Testosterone deficiency and infertility are major manifestations of male hypogonadism. Hypogonadism is often used to denote testosterone deficiency. Some clinical disorders in males present with infertility, but without testosterone

Table 1 Structure of testosterone and its derivatives

Generic name

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Pregnancy Guide

Pregnancy Guide

A Beginner's Guide to Healthy Pregnancy. If you suspect, or know, that you are pregnant, we ho pe you have already visited your doctor. Presuming that you have confirmed your suspicions and that this is your first child, or that you wish to take better care of yourself d uring pregnancy than you did during your other pregnancies; you have come to the right place.

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