Central Nervous System Disorders Psychiatric and Neurodegenerative

Disorders of the CNS are broadly categorized as either psychiatric or neurodegenerative with a major degree of overlap in symptoms. Thus neurodegenerative disorders also have a high incidence of psychiatric comorbities including anxiety and depression. Psychiatric disease includes a variety of disorders such as schizophrenia, depression, obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), and others. The underlying pathology is usually considered to be the result of synaptic dysfunction driven by: (1) a dysregulation of neurotransmitter availability or (2) signaling, the latter at the receptor and/or signal transduction levels. The net result is an alteration in neuronal circuitry involving multiple neurotransmitter/neuromodulator systems.

Neurodegenerative disease involves a defined degenerative process in which neurons are lost either by necrosis or apopotosis. This category is typified by slow chronic disorders that include Parkinson's disease and AD, but also includes more acute cell loss due to traumatic insults including stroke (brain attack) and spinal or brain damage. There are major issues with diagnosis in the absence of robust biomarkers.6 For example, there are cases where the AD disease phenotype is predominant and where the diagnosis of AD has not been supported by autopsy.

Free Yourself from Panic Attacks

Free Yourself from Panic Attacks

With all the stresses and strains of modern living, panic attacks are become a common problem for many people. Panic attacks occur when the pressure we are living under starts to creep up and overwhelm us. Often it's a result of running on the treadmill of life and forgetting to watch the signs and symptoms of the effects of excessive stress on our bodies. Thankfully panic attacks are very treatable. Often it is just a matter of learning to recognize the symptoms and learn simple but effective techniques that help you release yourself from the crippling effects a panic attack can bring.

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