Pharmacokinetic Changes in CKD

Patients with CKD have alterations in all of the pharmacokinetic parameters; absorption, distribution, metabolism and elimination (ADME). These ADME

KAI\G Ed

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Bruce A. Mueller, Pharm D, FCCP

Department of Clinical Services, College of Pharmacy

University of Michigan, 428 Church Street

Ann Arbor, MI 48109-1065 (USA)

E-Mail [email protected]

changes have been well detailed [5] and must be considered by the clinician before instituting drug therapy. ADME changes in the CKD patient can result in changes in the disposition of a drug and its pharmacologic effect. In this article we address many issues surrounding pharmacotherapy and monitoring in the CKD patient and propose practical approaches to selected drug-dosing dilemmas.

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