Senescent Phenotype

The senescence response entails many changes in cellular phenotype, such that senescent cells are strikingly distinct from their nonsenescent or presenescent counterparts. The senescence-acquired traits constitute a profile of characteristics that collectively are termed the senescent phenotype (1,27). The fundamental features of the senescent phenotype are an irreversible arrest of cell proliferation and cell type-specific changes in differentiated cell functions. In addition, in some cell types, cellular senescence causes resistance to signals that induce apoptotic cell death. Much more is known about the mechanisms responsible for the growth arrest than what might be responsible for the resistance to apoptosis or altered functions.

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