Mismatch Repair

Mismatch repair (MMR) removes nucleotides that have been mispaired by DNA polymerases during DNA replication and small insertions/deletions resulting from errors during replication of repetitive sequences or during recombination (13-15). Homologs of the bacterial mutS and mutL genes encode proteins that identify sub strates for mismatch repair. Different proteins recognize specific types of mismatches; others are used during meiotic recombination. The targeting of the strand for excision may depend on recognition of contact of the newly synthesized strand based with the replication complex. Additionally, factors important in DNA replication that also function in excision of the mismatch and resynthesis process include polS, pole, replication protein A, and others.

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