For several cell types, senescent cells are substantially more resistant than prese-nescent cells to dying in response to apoptotic stimuli. These cell types include human fibroblasts, T lymphocytes, and certain epithelial cells, such as keratinocytes
(115-117). Very little is known about the mechanisms that are responsible for senescent cells' ability to resist apoptotic death. However, the resistance to apop-tosis may explain why senescent cells accumulate in some tissues in vivo (118-122). That senescent cells are resistant to apoptosis underscores the distinction between cell death and cell senescence (123).
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