Systemby System Review

1. Central Nervous System Disorders

The primary disorders noted in aging individuals with DS are epilepsy and generalized decline in cognitive abilities often attributed to AD.

a. Epilepsy

The prevalence of seizures in people with DS appears to be highest in infancy and late in life. Seizures occur in 5-10% of children with DS (3). Different seizure types have been reported, including infantile spasms, tonic-clonic, and myoclonic, generalized seizures. In the studied population, seizures occurred in 50% (9/18) of patients with DS in the younger group and in 55% (11/20) of pa-

Table 1 Demographic Information on Down Syndrome Adults (DS-A) Residing at Woodlands
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