Pediatric versus Adult Care Specialists and Facilities

A central, complex issue is the choice of the most appropriate specialist who will manage care for the older adolescent and young adult cancer patient - a pediatric oncologist or an adult oncologist (medical, radiation, surgical, or gynecologic oncologist). For older adolescents, the site of diagnosis and treatment may be problematic since, at least in theory, these patients could be treated at either a pediatric or adult care facility. Leonard and his colleagues in the United Kingdom have...

Contributors

44 Binney Street, Boston, MA 02115, USA 1515 Holcomer Bird., Houston, TX 77030, USA 4650 Sunset Boulevard, Los Angeles, CA 90027, USA 1280 Main Street West, Hamilton, Ontario, L8S 4J9 Canada Department of Hematology Oncology Children's Hospital and Clinics of Minnesota 2525 Chicago Ave. S, MS 32-4150, Minneapolis, MN 55404, USA City of Hope Medical Center, 1500 East Duarte Road Duarte, CA 91010-3000, USA Paediatric and Familial Cancer Research Group University of Manchester and Royal Manchester...

Archie Bleyer Karen H Albritton Lynn AG Ries Ronald Barr

1.2.1 Classification System 2 1.2.2.1 Age-Specific Incidence 3 1.2.2.2 Gender-Specific Incidence . . . 3 1.2.2.3 Ethnicity-Specific Incidence . . 4 1.2.2.4 Types of Cancer 4 1.2.2.5 Trends in Incidence 6 1.2.3 Mortality and Survival 7 1.2.3.1 Age- and Gender-Specific Mortality . . . . . . . . . . . . . . 7 1.2.3.2 Ethnicity-Specific Mortality . . 8 1.2.3.3 Trends in Mortality 8 1.2.4.1 Conditional Survival 12 1.2.5 Etiology and Risk Factors 15 1.3.1 Signs and Symptoms 15 and Pathologic...

References

Bleyer WA, OLeary M, Barr R, Ries LAG eds 2006 Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, including SEER Incidence and Survival, 1975-2000. National Cancer Institute, NIH Pub. No. 06-5767, Bethesda MD, June 2006 also available at www.seer.cancer.gov publications 2. Ries LAG, Eisner MP, Kosary CL, et al 2002 SEER cancer statistics review, 1973-1999. National Cancer Institute, Bethesda, MD 3. Chaganti RS, Rodriguez E, Bosl GJ 1993 Cytogenetics of male germ...

Introduction

The history of adolescent and young adult oncology, as a distinct entity, is relatively short. Nevertheless, the true chronicle of cancer in the young is centuries old. Such history is inevitably intertwined with that of cancer and medicine. While reports of adolescents and young adults are not specifically recorded, evidence indicates that cancer in adolescents precedes and transcends human written history 1-3 . The types of cancer most prevalent in this age group have been found or reported...

Genitourinary Function 27291 Renal

Long-term renal damage in individuals treated for cancer is most often associated with drugs such as cisplatin or ifosfamide, and radiation therapy. Cisplatin can damage the glomerulus and distal renal tubules, potentially causing diminished glomerular filtration rate GFR and electrolyte wasting, most commonly involving magnesium, calcium, potassium, and sodium 90 . Ifosfamide damages the proximal renal tubule, potentially resulting in Fanconi's renal syndrome hypokalemia, hypophosphatemia,...

Synovial Sarcoma

SS probably represents the most frequent malignant tumor of soft tissues in adolescents and young adults, accounting for about 15-20 of all cases. The optimal treatment approach to SS remains to be determined. As for other STSs of adult age, the standard treatment for localized disease is surgery. Complete surgical resection of the primary tumor is the unquestionable mainstay of treatment. Extensive surgery with histo-logically free margins is recommended compartment resection is the treatment...

Differentiated Thyroid carcinoma 1631 Epidemiology

Epidemiology Thyroid Cancer

In childhood, thyroid carcinoma is more a disease of teenagers, with the approximate median age of diagnosis being 15 years 4 . The incidence of DTC varies from 0.5-1.5 cases million year in children less than 15 years of age to 14.6, 36.1, and 53.2 cases per million per year in the 15-19, 20-24, and 25-29 year age groups, respectively 2, 5 . DTC is more common in females, and the female male incidence is greater than 5 1 in adolescents and young adults 1, 2 . This sex difference is not...

GcTs treatment Issues

The current treatment regimen for all patients with resected early-stage GCTs of the ovary is adjuvant therapy with bleomycin, etoposide, and cisplatin BEP 55 . The only exceptions to this schema are patients with stage IA or IB, grade 1 immature teratoma, and stage IA pure dysgerminoma. These patients should not receive adjuvant chemotherapy, but should be closely observed following surgery 56 . In addition, there is also an increasing body of literature supporting no post-surgical treatment...

Germcell tumors

Historically, patients with malignant ovarian GCTs treated with surgery alone had a poor survival rate. Prior to the consistent use of chemotherapy, the outcome for patients with ovarian non-germinomatous tumors was poor, with survival rates of 15-20 70 . Patients with germinomatous tumors could be cured with surgery alone 71, 72 or with surgery combined with chemotherapy 73, 74 . In the POG CCG Intergroup studies, patients were assigned treatment based on tumor histology immature teratoma and...

Other Conditions with Increased Risk of CNS Tumors

People with Down syndrome have a reduced overall risk of CNS tumors, although the risk of intracranial GCTs is increased 75 . Gorlin syndrome is strongly associated with medulloblastoma, and germ-line mutations in the INI1 gene are associated with atypical teratoid rhabdoid tumors, although both of these associations occur almost exclusively in early childhood and are therefore not applicable to the age-focus of this chapter 76-79 . Finally, there are reported medulloblastomas presenting in...

Survivorship Guidelines httpwwwsurvivorshpguidelinesorg

The Children's Oncology Group has posted guidelines for long-term follow-up of pediatric cancer that may help the adolescent and young adult with cancer, including following topics Introduction to Long-Term Follow-Up Emotional Issues Finding Appropriate Healthcare after Cancer Health Promotion via Diet and Physical Activity