Natural Childbirth Options

Bump To Birth

The experience that a woman has during childbirth shapes how the rest of her child-raising experience goes, in many ways. A good birth can have a huge effect on how good you feel about your child, whereas a bad birth can often lead to feelings of sadness or PDST-type symptoms due to the pain and struggle of the birth experience. However, you don't need to worry about that now, because the information in this book gives you ALL of the experience and expert advice that you need in order to have a really amazing birth, that really marked that day as the truly special day that it is. This book teaches you how to use natural, holistic remedies to heal yourself during pregnancy in order to make sure that you feel your best during the whole birth experience. You can also learn everything you need to know about natural birth Everything you need to know to have a great pregnancy and birth is in this guide! More here...

Bump To Birth Overview


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Diversity in Patterns of Health and Aging

Methodological difficulties encountered in the processes of sampling, designing valid interview protocols, achieving subject cooperation, and controlling interviewer and subject bias have hampered attempts to generalize about the health and other characteristics of black, Hispanic, American Indian, and Asian populations in the United States. However, in key areas such as life expectancy, prevalence of chronic health conditions, residential patterns, and education, significant differences have been documented across groups. In the United States in 2001, average life expectancy from birth was 5.5 years longer for white persons than for black Americans (Federal Interagency Forum on Aging-Related Statistics 2004). At age 65, however, the life expectancy gap narrowed to about 2 years, and by age 85, life expectancy was slightly longer for older black persons compared with white persons. In 2000-2001, among people age 65 and older, hypertension and diabetes were more common among black than...

Age Specific incidence

Incidence of all invasive cancer in the United States from 1975 to 2000 as a function of 5-year age intervals from birth to 85+ years. The ordinate is linear in A and logarithmic in B. The straight line in B indicates that the incidence is exponentially correlated with age from 10 to 55 years, and throughout the adolescent and young adult years. Surveillance, Epidemiology and End Results (SEER), 1975-2000 Figure 1.1 shows the incidence of all invasive cancer in the United States from 1975 to 2000 as a function of 5-year age intervals from birth to 85+ years. The straight line in Fig. 1.1B, which is presented on a logarithmic scale, indicates that the incidence increases exponentially with age from 10 to 55 years, and throughout the adolescent and young adult years, which suggests that a common age-dependent oncogenic process is active, such as telomerase shortening, or that the mutation-to-malignancy rate constantly increases with age.

Gender Specific incidence

Figure 1.2 shows the incidence of all invasive cancer in the United States from 1975 to 2000 as a function of 5-year age intervals from birth to 85+ years separately for females (Fig. 1.2A) and males (Fig. 1.2B). Females demonstrate the exponential risk pattern from age 10 to 50 years. Males have a third peak that appears during the young adult age range, at approximately Incidence of all invasive cancer in the United States from 1975 to 2000 as a function of 5-year age intervals from birth to 85+ years among females (A) and males (B), each expressed on semi-logarithmic coordinates. SEER, 1975-2000

Involving the public in designing trials and setting research agendas

Setting and implementing health research priorities is a complex and sometimes obscure process. Although the aim should be that the views of all stakeholders are considered, with few exceptions (notably the Childbirth and AIDS advocacy movements), patients and consumers have little input to how research is prioritized, funded and monitored 41 .

The first step investigation of patterning

The analyses presented by van Schaik et al. (Chapter 8) illustrate the centrality of investigating patterning to the comparative method. Data were collected for primate species for a wide range of features such as the incidence of infanticide, infant care styles, whether lactation is longer or shorter than gestation, mating patterns during pregnancy, the presence or absence of post-partum oestrus, the development of sex skin, and whether females produce calls related to mating. These data were examined to determine whether the pattern of distribution across species of variants of one feature is associated with that of another - the basic requirement if variables are causally or functionally related. For example, the species in which the mother alone carries the infant do not have post-partum oestrus, whereas most of those which park their infants, or in which carrying is shared with other individuals, do. In Ross and Jones' study (see Chapter 4), patterning is similarly fundamental,...

Tiziana Lazzarotto Maria Paola Landini

The infants may acquire infection from the mother as a result of intrauterine infection (congenital infection), or through contact with infected genital secretions during passage through the birth canal (perinatal infection) or postpartum through breast feeding (postnatal infection).

Monitoring Blood Banks

With reporting the first human blood transfusion. In 1818, Dr. Blundell gave blood to a patient who was bleeding heavily after giving birth, using blood from her husband. Over the next several years, Dr. Blundell did ten more blood transfusions, and five of them helped his patients.

Studies in MS and Other Conditions

Symptoms of MS that have been investigated in some aromatherapy research are anxiety, depression, pain, and insomnia. For anxiety, studies of variable quality indicate that beneficial effects may be obtained with the use of lavender oil, Roman chamomile oil, and neroli (orange) oil. However, no large, well-designed clinical studies have examined this antianxiety effect. Preliminary information suggests that a lower dose of antidepressant medication may be needed by depressed men when the medication is used in combination with aromatherapy using a citrus fragrance. Lavender in bath water does not appear to relieve childbirth-associated pain. Positive and negative results have been obtained in other studies of aromatherapy and pain. Several fragrances, especially lavender, have been evaluated in sleep studies in animals and humans. Some positive results have been reported, but these studies are of variable quality.

Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults

In an autopsy study of the evolution of atherosclerotic lesions in young people, we obtained the coronary arteries and aortas of 1160 male and female subjects who died between full-term birth and age 29 years. In this article, we report the light and electron microscopic observations of the coronary arteries of 565 of these subjects in which we fixed the coronary arteries by perfusion with glutaraldehyde under pressure. From birth, the intima was always thicker in the half of the coronary artery circumference opposite the flow-divider wall of a bifurcation (eccentric thickening). In cases where we found lipid in the intima, there was always more in eccentric thickening. Isolated macrophage foam cells in the intima of infants were the earliest sign of lipid retention. These cells occurred in 45 of infants in the first 8 months of life but decreased subsequently. At puberty, more substantial accumulations of macrophage foam cells reappeared in more children. Foam cells were now...

Classification System and Methods

Incidence and survival in this chapter are presented for 15- to 29-year-olds, with comparisons to the age groups 0-15 years and 30-44+ years, as appropriate. For some analyses the entire age range from birth to 85+ years is included. The absence of data in any figure or table within this chapter means that too few cases were available for analysis it does not mean that the rate or change in rate was zero.

Risk Of Neonatal Infection

As indicated in the preceding section, it is the woman with primary genital HSV infection who is at highest risk of transmitting HSV to her newborn baby during birth. Despite this fact, considerable attention is focused clinically on the woman with a history of genital HSV that preceded her current pregnancy. Prenatal cultures of the vaginal tract do not predict whether a woman with a history of genital HSV will be shedding virus at the time of delivery (27) and as such have no role in the evaluation of such women. There is active debate in the obstetrical community regarding whether, for women with known recurrent HSV disease and active lesions at delivery, the surgical risks of cesarean delivery outweigh the small (< 2 ) risk of the baby contracting neonatal HSV. At the current time, however, women with active lesions noted at the time of labor are delivered by cesarean section to minimize risk of transmission to the baby, regardless of whether they have recurrent infection or...

Ontogenic development

By UGT2B7.107 Morphine was found to undergo significant glucuronidation by the fetus liver. In vitro studies in hepatic microsomes obtained from fetuses (15-27 weeks) indicated that the glucuronidation rates were 10-20 of that observed in adult microsomes.108 In addition, the mean rate of morphine glucuronidation in fetal livers obtained after hysterectomy was twofold higher than that obtained from induced abortion livers, suggesting a possible regulatory mechanism for UGTactivity related to the birth process (Table 4).25 The glucuronidation of morphine in vivo has also been demonstrated in premature neonates as young as 24 weeks of gestation. Studies with other substrates which are mainly or partially glucuronidated by UGT2B7, such as naloxone, an opiate agonist, benzodiazepines, and nonsteroidal antiinflammatory drugs are all suggestive of a reduced glucuronidation ability in neonates compared to adults.109

Caroline Ross And Kate E Jones

The intrinsic rate of population increase depends on three variables age at first reproduction (AR), birth rate (b) and age at last reproduction (L). Birth rate has an important influence on the rate of population increase, which is illustrated by the examples given of Macaca silenus and Macaca sylvanus the females of which start breeding at about five years of age. However, in Macaca sylvanus, birth rate is higher, leading to a higher intrinsic rate of population increase. Animals that start breeding at an early age also show a higher intrinsic rate of population increase than do those that start breeding later. This has a knock-on effect over the generations, as a female that breeds early produces female infants that also breed early, thus increasing the total number of females that are producing infants. For example, both Macaca sylvanus and Erythrocebus patas breed annually, but E. patas reaches maturity nearly two years before M. sylvanus. Over time, this difference in AR has a...

Incidence And Sources Of Cytomegalovirus Infection

CMV can be transmitted from mother to child transplacentally, during birth, and in the postpartum period via breast milk. Congenital CMV infection rates are directly related to maternal seroprevalence rates. Rates of congenital CMV infection are higher in developing countries and higher for low-income groups in developed countries (7,10,29). The mechanisms for this increased rate of congenital CMV in populations with high seroprevalence rates are not clear. Studies of risk factors for congenital CMV infection have also documented an association between young maternal age and increased rates of congenital CMV infection (30). Preece at al. also found that non-white race and single marital status were independently associated with increased risk of congenital CMV infection (31). Fowler et al. reported an increased risk of congenital CMV infection in women with sexually transmitted diseases, single mothers, and those younger than 20 years (32).

Asad Ansaria Adriana Weinbergb

A cohort of 277 children from birth through 2 years with weekly testing of saliva for HHV-6. HHV-6 has also been associated with myelodysplastic syndrome, hemophagocytic syndrome, infectious mononucleosis, thrombocytopenia with and without purpura and in more rare instances, dilated cardiomyopathy and acute lymphadenitis including Rosai-Dorfman diseases (a rare, benign, pediatric lymphadenopathy) (Levine et al., 1992 Saijo et al, 1995 Syruckova et al., 1996 Yoshikawa et al., 2001 Hashimoto et al., 2002 Maric et al., 2004 Kagialis-Girard et al., 2005). Recently, a case of acute respiratory distress syndrome secondary to HHV-6 pneumonia has been described in an immunocompetent young female (Merk et al., 2005). HHV-6 has also been implicated in chronic fatigue syndrome without clear proof.

Dimension of the Nutritional Problem in the World

International organisations (UNO, FAO, WHO, UNICEF, World Bank) have established methods of evaluating available foods, the consumption of food, and nutritional status by taking into consideration parameters of agricultural production, anthropometrical measurements, birth-rate, mortality and morbidity rates, and clinical, immunolog-ical, haematological, and biochemical parameters. Mothers may give birth to underweight babies. The situation is particularly serious in sub-Saharan Africa, where acute malnutrition occurs more often, while the majority of chronically hungry people is in Asia and the Pacific area. Teenage mothers and their babies are particularly vulnerable to malnutrition. Girls generally grow in height and weight until the age of 18 and do not achieve peak bone mass until about 25. The diet of a chronically hungry adolescent girl cannot support adequately both her own growth and that of her foetus. Malnourished young women often give birth to underweight babies.

Congenital And Perinatal Infection

The possibility of EBV acquisition by neonates during passage through the birth canal has been raised by the results of a study in which cervical shedding of EBV was demonstrated in 5 out of 28 (18 ) seropositive women (13). However, no clear data are available regarding the incidence of perinatal transmission of EBV.

Motor Neuron Diseases

Motor neuron diseases (MNDs) are characterized clinically by a progressive loss of muscle power brought about by the primary degeneration of lower or upper motor neurons or both. In lower MNDs, the weakness is associated with muscle wasting, fasciculation, hypo-tonia, and a decrease or loss of tendon reflexes. In upper MNDs, the weakness is associated with spasticity, hyperactive reflexes, and Babinski sign. Some diseases are sporadic, and some inherited. Individuals of all ages from birth to late midlife can be affected. The diagnosis depends primarily on the symptoms and signs. An elec-tromyogram (EMG) showing a denervation pattern confirms degeneration of the lower motor neurons.

Intraspecific variation

Across primate species, infant mass at birth is a constant proportion of maternal mass, but the relative mass of the neonate (as a proportion of maternal mass) declines with maternal size. Larger species give birth to a proportionately smaller neonate. Within rhesus macaques, larger individual mothers give birth to larger neonates (Bowman and Lee, 1995) and larger mothers appear to be more efficient at sustaining fetal growth as gestation length varies little. However, as found in interspecific comparisons (see also Reiss, 1985), the infants of larger macaque mothers were a relatively lower proportion of their mothers' mass. The patterns are similar between and within species, although with lower slopes, as has been predicted (Kozlowski and Weiner, 1997).

In Vivo Activities Of Mcp1

In another model, murine MCP-1 was expressed under the control of a rat insulin promoter (RIP-MCP-1 transgenic mice) (57). From birth these mice displayed a mononuclear insulitis consisting almost entirely of F4 80+ monocytes with very small numbers of CD4+, CD8+, or B220+ cells. (Although B220 is also expressed on NK cell surfaces, these are unlikely to be NK cells because they were not stained by the NK marker, NK1.1.) Notably, despite an impressive infiltrate, these mice never became diabetic, suggesting that MCP-1 can attract monocytes efficiently but cannot activate them to engage in tissue destruction.

Volunteer collaboration

Volunteers should be from the community in which they work, even in emergencies. They should work with their elders, leaders and local health staff (health workers and traditional birth attendants). Volunteers should know the traditional beliefs about diseases and know what priority health problems the community wants to solve. They should also know what other groups are doing in their community about priority health problems and know the families and visit them regularly to provide key messages.

Pharmacodynamic Modeling of the Clonal Growth of Initiated Liver Cells

To express the clonal growth model in mathematical terms, the growth kinetics of normal hepatocytes depend on the cell birth rate, a, and death rate, P where N is the number density of normal hepatocytes in the tissue. Initiated cells are produced through mutations in the normal hepatocytes from dieth-ylnitrosamine treatment. This is assumed to be a stochastic process that follows a Poisson distribution. The expected number of initiated cells in a small time step is defined by a function of mutation probability and cell birth rate

Purulent Leptomeningitis

Purulent leptomeningitis occurs at all ages from birth through old age. The age-related preferences of common bacteria are listed in Table 6.2. The onset is sudden, with fever, headaches, photophobia, and nuchal rigidity. Severe cases are complicated by an altered state of consciousness, seizures, cranial nerve deficits, and focal neurologic symptoms and signs. The cerebrospinal fluid (CSF) shows elevated cell count, chiefly with polymorphonuclear leukocytes (PNLs), increased protein levels, and decreased glucose levels. The causative microorganisms are identified in the sediment of the CSF using Gram stain and by culturing the CSF and blood. Polymerase chain reaction (PCR) and immunologic techniques identify the bacteria within hours of onset.

Scope and Context of the Issue

For millennia mankind has sought relief from pain by using medicines. Ancient texts refer to the use of many herbal remedies for pain. In the first century Emperor Claudius' personal physician recorded detailed instructions on the preparation of opium and Galen recommended the juice of the poppy for the relief of pain in older persons. Cannabis was a remedy with known pain relieving effects in use in Ancient China 1 , Persia, India, Egypt, Greece and Rome. The bark of the willow (from which aspirin is derived) was one of the many herbal remedies used by Sumerian, Egyptian, Greek and Roman physicians. In Hippocratic writings it was praised for combating the pains of childbirth and fever 1 .

Definition frequency and pathogenesis

During the perinatal period, maternal varicella can infect the baby by (i) trans-placental viremia, (ii) ascending infection during birth, or (iii) respiratory droplet direct contact with infectious lesions after birth. Chickenpox occurring in the first 12 days of life is described as intrauterine-acquired neonatal varicella. The disease can be expected if a mother contracts chickenpox during the last 3 weeks of pregnancy. Intrauterine-transmitted neonatal chickenpox has been occasionally referred to as ''congenital varicella'' or ''neonatal varicella syndrome'' (Sauerbrei and Wutzler, 2001). These terms should be avoided, since they do not allow a clear differentiation from the CVS caused by maternal chickenpox in the first two trimesters.

Effects On The Fetus And Neonate

Although maternal poliomyelitis in the first two trimesters can be associated with spontaneous abortion or stillbirth and can predispose to intrauterine growth retardation and premature delivery, poliovirus infection of the fetus was an infrequent occurrence in the prevaccine era (2-7). Maternal poliovirus infection was not linked to an increased incidence of congenital anomalies (8). Neonatal poliomyelitis was a complication of maternal infection, however. Cases presented from birth to 28 days of age, with most cases occurring between days 5 and 21. The incubation period of neonatal poliomyelitis was often shorter (< 11 days) than that observed with poliomyelitis acquired at a later age. Symptoms included anorexia and lethargy, and paralytic disease was frequent. Fever was variable, and diarrhea occasionally was present. Reports of neonatal

Cervical and Lumbar Epidural Injections

Epidural injection involves the placement of a therapeutic substance immediately outside the outermost and thickest protective covering of the spinal cord and the fluid in which it resides. It is a standard part of the practice of anesthesia and has, for instance, revolutionized the provision of pain relief in childbirth. The use of epidural steroid injections for low back and leg pain dates back many decades. There are a number of anecdotal reports of efficacy and a number of uncontrolled studies, which at best provide conflicting evidence.

Congenital or Acquired Muscle Weakness

The insertions of the extraocular muscles as a possible cause of squint. There is a group of conditions, known as musculofascial anomalies, in which there is marked limitation of the eye movements from birth in certain directions. They are accompanied by abnormal eye movements, such as retraction of the globe and narrowing of the palpebral fissures on lateral gaze.

Clinical Features

Although the reported incidence of progeria in the United States is about 1 in 8 million births (1), the true population incidence may be somewhat higher, as not all cases are reported. Based on our experience, we estimate that about 50 of all cases in the United States are reported, which leads to an estimate of incidence of 1 in 4 million. This would still lead to a much higher expected consanguinity frequency (45 ) than the low frequency that is seen in families in which progeria occurs. This lack of consanguinity suggests progeria is unlikely to be a rare recessive condition.

Timing Of Hiv1 Transmission

Infants may be infected in utero through transplacental spread, during labor and delivery through contact with infected blood or secretions in the birth canal, and post-natally through breast-feeding. In countries where women are counseled not to breastfeed, most transmission occurs at the time of delivery. In countries where safe alternatives to breast-feeding are not available for infant nutrition, many infants are infected through breast-feeding. The timing of transmission is defined by the time that HIV-1 is detected in the infant using a standard diagnostic test (20,21). Cord blood should not be used for HIV-1 testing of the infant at birth because of the potential for contamination with maternal blood. If tests that detect the HIV-1 virus, such as an HIV-1 culture or HIV-1 DNA polymerase chain reaction (PCR) assay, are positive within the first 48 hours of life and subsequent tests are also positive, the transmission is considered to have occurred in utero. However, if the HIV-1...

Dengue Infection In The Pregnant Woman

Reports of dengue infections have come from Guadeloupe (one mother developed severe thrombocytopenia, giving birth via cesarean section, and the other had preterm labor mothers and infants recovered without complications) and from Thailand (thrombocytopenia with and without hemorrhagic complications) (27-29).

Suppression of Autoimmune Disease by Regulatory Cells from Donors with or Without the Relevant SelfAg

In view of differential suppression of autoimmune prostatitis (AIP) and autoimmune thyroiditis by T cells from Ag-positive vs Ag-negative cell donors (described below), how do we explain their equal suppression of AOD Our interpretation is that even if the regulatory capacities of male and female CD4+CD25+ T cells for AOD suppression are different, they are equalized when the cells encounter the endogenous ovarian Ag in the young d3tx host. Indeed, we have shown that ovarian Ags (mater and ZP3) are expressed from birth and have the capacity to stimulate T cells on day 3 (Alard et al. 2001). This is also exemplified by the process of diversified autoAb response that depends on de novo B cell response to endogenous ovarian Ag. Immunized female mice with a ZP3 peptide that contains T but not native B epitope (in CFA) elicited Ab response to a distant native ZP3 B cell epitope within 7 days, 2 days after detectable response to the ZP3 T cell epitope (Lou et al. 1996). Other examples of...

Epidemiology And Transmission

Among adults, epidemiological studies support sexual activity as a route of spread for GBS (8). Mother-to-infant transmission of GBS can occur either prior to birth by the ascending route through ruptured membranes or at the time of delivery by contact with the organism in the birth canal. Less commonly, infants may acquire GBS through

Importance Of Summary Statistics In Estimating Population Parameters

The roots of coalescent theory can be found in work as early as the 1930's (Wright, 1931 Fisher, 1930) and 1940's (Malecot, 1941). However, it took the imagination and persistence of Kimura (1983). Ewens (1972 1979), Watterson (1975) and others to propose the importance of neutral evolution of nucleotide sequences and develop the theory required to give birth to the coalescent theory (Kingman, 1982 Hudson, 1990). The first developments of neutrality theory and coalescents that showed the power of summary statistics methods appear in work by Watterson (1975), Hudson (1990 1993) and colleagues (Kaplan et al. 1989), Strobeck (1987), Tajima (1983 1989a 1989b 1989c 1993 1997), Griffiths (1989), Tavare (1984) and Takahata (1991). Some of these works pointed to new methods utilizing summary statistics for hypothesis testing of neutrality, estimation of 6 using sequence data, and investigation of the role of migration and recombination rates in producing observed patterns of neutral sequence...

Peripheral Nerve Injury Produces an Increased Expression of Clusterin in CNS Neuronal Perikarya

Motoneurons already express low levels of immunoreactivity for clusterin from birth. These levels tend to increase during early postnatal development (Tao, Aldskogius, unpublished observations).3 One-two weeks after injury of motor axons in adult animals, clusterin immunoreactivity and labeling for its mRNA are increased (Fig. 8.2).2,4 This upregulation does not occur uniformly in the population of axotomized motoneurons but predominate in regionally distinct groups. Under the same lesioning conditions in immature rats immu-noreactivity for clusterin appeared to be increased a few days after injury in virtually the entire population of affected motoneurons (Tao, Aldskogius, unpublished observations). These two experimental situations show important differences with respect to neuronal vulnerability. Neonatal injury produces rapid and extensive nerve cell death, but adult injury produces little nerve cell death and that only after a protracted postoperative survival time.

The Social Consequences of Genetic Disclosure

The social consequences of disclosure of genetic information are as varied as the societies in which such disclosure occurs and depend on the local social meanings attached to the information disclosed. For example, at one extreme, the simple knowledge of whether a fetus has the Y chromosome (which determines sex) can be, and has been fatal for the fetus. Long before the advent of prenatal detection technologies, preference for a male child in India was so great that a notable fraction of the population practiced infanticide of newborn females. Once technologies for determining sex became available, the quest for disclosure took an ominous turn. An excerpt from a general letter sent out in early 1982 by Bhandari Hospital in India, states Most prospective clients in quest of a male child, as the social set-up of India demands, keep on giving birth to a number of female children, which in a way not only enhances the increasing population, but leads to a chain reaction of many social,...

Primary Intracranial Tumors In Children

In the pediatric age group, intracranial tumors are the most common tumors after leukemias. They are a major cause of cancer-related death in children. They may present at any time from birth on. Fetal tumors can be detected by the third trimester using ultrasonogra-phy investigations are usually prompted by a sudden increased rate of uterine growth.

Neurodegenerative Diseases

Dlugosz et al. 76 investigated a possible relationship between the use of electric bed heaters and birth defects. They asked mothers of children born with cleft palates or neural tube defects if they had used an electric bed heater during the 4 months around the estimated date of conception. A total of 663 case mothers were matched with a similar number of control women who had given birth to children without birth defects. The comparison showed that mothers of children with birth defects were no more likely to have used an electric bed heater than other mothers.

Risk Of Fetal Or Neonatal Infection When Infection In The Mother Is Diagnosed Or Suspected

An infant born to a woman with active cervical infection with C. trachomatis is at risk of acquiring the infection during passage through the infected birth canal. Approximately 50-75 of infants born to infected women become infected at one or more anatomic sites, including the conjunctiva, nasopharynx, rectum, and vagina (Table 1). Overall, the nasopharynx is the most frequently infected site in the infant. Approximately 30-50 of infants born to Chlamydia-positive mothers will develop conjunctivitis (11-14). Studies in the 1980s identified C. trachomatis in 14-46 of infants younger than 1 month of age presenting with conjunctivitis. Chlamydia ophthalmia appears to occur much less frequently now secondary to systematic screening and treatment of pregnant women. The incubation period is 5-14 days after delivery. C. trachomatis is usually not detectable in the eye or nasopharynx immediately after birth unless there has been prolonged rupture of membranes. At least 50 of infants with...

Teratogenicity Of Chemotherapeutic Agents

Caligiuri and Mayer23 reported on leukemic pregnant patients treated with cytarabine as either a single agent or in combination. Eighteen of these women gave birth to normal offsprings, and five pregnancies ended in elective abortions. Another AML patient was 20 weeks pregnant when treated with cytarabine and daunoru-bicin she received reinduction with mitoxantrone and cytarabine. She subsequently underwent consolidation therapy with one cycle of cytarabine and idarubicin between weeks 29 and 30. Two days later she delivered a stillborn but phenotypically normal infant.30

Observations and Avenues for Future Action

Although we are still early in the operational phase, which will shortly give birth to the expert centers for chronic pain, some mobilization is already observable among the universities and institutions shortlisted to become expert centers. Additionally, Qu bec's Health Research Fund5) (FRSQ) has flagged pain research, and more particularly chronic pain research, as one of its priorities in its latest strategic development plan. This has led to the creation of a Quebec network for pain research (RQRD6)) comprised of researchers active in the four Qu bec universities with a faculty of medicine. There are plans in the current process to develop a large clinical research component centered on the emerging service network.

Congenital And Neonatal Infections

The most common pathogens of congenital and neonatal infections are viruses and the protozoa Toxoplasma gondii. Bacteria and the spirochete Treponema pallidum are less common. (See Chapter 6 on infectious diseases.) Fetuses are infected transplacentally, and neo-nates are infected during delivery through an infected birth canal or by breast feeding with infected milk. The maternal infection may be acutely acquired or more often results from reactivation of a clinically latent infection. Infections during the first trimester produce the most widespread injuries, notably inflammatory destructive lesions in the brain, sensory organs, and viscera, and malformations (Table 14.4). Among the major malformations are hydranencephaly, polymicro-gyria, hydrocephalus, and microcephaly. The neurologic sequelae of infections acquired later in gestation are mental retardation visual, auditory, and motor deficits and seizures. Maternal infections are diagnosed by sero-logic tests, and fetal...

Incidence and Causes of Blindness

In England and Wales, the prevalence of blindness in 1980 for children under five years was 9 100,000. This figure increased to 2324 100,000 for adults over 75 years. In the western world, blindness in children is largely because of inherited genetic disease and birth trauma. In adults aged 20-60 years, the major causes are diseases of the retina, including diabetic retinopathy and optic atrophy. Over the age of 60 years, macular degeneration, glaucoma and cataract are the important problems.

Sex and social evolution in primates

Place during the cycle in which fertilisation occurs, the male rule can be simple if he mated with the female, his paternity is ensured. Field studies on primates with unimale groups suggest that when a newly immigrated male mates with a pregnant female, the probability that he will subsequently commit infanticide is reduced (e.g. blue monkey Fairgrieve, 1995 hanu-man langur Sommer, 1994), although it is not clear how long before birth this mating must take place. Experimental work on rodents confirms these rules (Perrigo and vom Saal, 1994). Where multiple males mate with the female before she gives birth, more complex rules are needed these have not been studied in detail. Unfortunately, there are no data to test the assumption that the degree of unpredictability depends on the need for confusion. However, the concept of unpredictable ovulation also suggests that there should be a good but not perfect correlation between male rank and paternity, with a small proportion of infants...

Historical Context

The main topic Walker addresses in Possessing the Secret of Joy is how the female genital mutilation ritual in a specific African tribe affects the mind, body, and spirit of its bicultural protagonist, her family, and her countries. However, it is necessary to note that Walker's literary representation of FGM applies to only a small percentage of African tribes and that the surgical ritual is conducted in many different ways, in hospitals as well as in huts, for many different reasons. For these general purposes, the procedure is more descriptively called female genital cutting (FGC) because, by degree, it ranges from a slight ceremonial nicking of the clitoris to draw blood to the more radical excision (removing some or all of the outer genitals) and infibulation (sewing up the vagina and leaving a small opening for urination and menstrual flow). The ritual's end result spans the gamut from a proud youth who has experienced a spiritual initiation into adulthood and elevated tribal...

Literary Analysis

Possessing the Secret of Joy is a vehicle for Walker's own feminist agenda. By putting Tashi into a particular context, Walker is able to develop her human rights and health issues as well as argue for political change. Tashi's story becomes part of Walker's own. For instance, the autobiographical elements are clear when Walker refers to FGM as sexual blinding, a reference to her brothers shooting her in the eye and swearing her to silence. Both Walker and her character Tashi aborted a pregnancy and bridged cultures in search of an identity. They are storytellers whose myths teach lessons, filling the novel with stories of repression, of struggles, and eventually of self-actualization. Walker's strong female character, Adam's lover Lisette (Walker's alter ego), is an altruistic white woman who, as the voice of reason, contrasts with the emotional Tashi. As a youth Lisette had visited Olinka with a church youth group, and her family were colonists in Algeria. As an adult she is a high...

Male Involvement with Infants

The main exception to a general pattern of ignoring interactions between males and infants was of course the study of male care among monogamous primates. It has been known for over 200 years, ever since a zoologist-illustrator named George Edwards decided to watch the behavior of pet marmosets in a London garden, that among certain species of New World monkeys males contributed direct care for infants that equalled or exceeded that given by females (Edwards, 1758). Mothers among marmosets and tamarins typically give birth to twins, as often as twice a year, and to ease the female in her staggering reproductive burden the male carries the infant at all times except when the mother is actually suckling it. It was assumed that monogamy and male confidence of paternity was essential for the evolution of such care (Kleiman, 1977), and at the same time, it was assumed that monogamy among primates must be fairly rare (e.g., see Symons, 1979, or virtually any textbook on physical...

An Aging World

For the first time in history, most people in societies such as our own can plan on growing old. Life expectancy from birth has increased dramatically in the United States, from about 47 years in 1900 to 77.3 years in 2002 (Federal Interagency Forum on Aging-Related Statistics 2004). Even those people who are currently old can expect to live for many years. For men at age 65, average life expectancy is more than 16 years, and for women at age 65, it is almost 20 years at age 85, men can expect to live 6 more years and women 7 years (Federal Interagency Forum on Aging-Related Statistics 2004).

Trends in Mortality

National mortality rate of all invasive cancer in the United States according to race, including American Indians Alaskan natives, in the period 1990-2000, as a function of age from birth to 45+ years National mortality rate of all invasive cancer in the United States according to race, including American Indians Alaskan natives, in the period 1990-2000, as a function of 5-year age intervals from birth to 44 years

Inner Cleansing

'Biological cleansing' is a biotechnology of perpetual motion, common to all species. Bio-perpetual motion runs on its own time. As in all other plants and animals our bodies respond obediently to the macrobiological rhythms of our solar and lunar 'body clocks', that prompt us through the years, months, days, and hours, ordaining the time to eat, sleep, give birth, grow, or die.1 Human body-cleansing also has its own physical calendars and clocks. Powerful daily circadian cycles regulate our total energy flow and all the major bodily processes, particularly the arrival and passing of the menses, the fetus, and the faeces. Micro-second cellular activity is constant but it is when we are asleep, or resting, that microbiological 'cleansing' can take place relatively uninterrupted. It is no accident that we cleanse ourselves in the morning from the evacuated remnants of our night's sleep just as we cleanse ourselves in the evenings from the remnants of the day's work.

Psychologic Stress

People react differently to the same stressful situation for many reasons, some outside of their control. Studies of infants suggest that differences in temperament are apparent even at a very young age. Some of these differences seem to persist throughout life. Parents with more than one child point out that almost from birth their children are dramatically different in their ability to tolerate change and stimulation. Patients frequently tell us that being high-strung or nervous runs in their family, and it appears that both genetic (inherited) and environmental factors play a role in an individual's ability to handle stress. Growing up in a household where others handled stress and change well, versus growing up in a household where people coped with stress in less healthy ways, such as drinking to excess or blaming others, clearly has an influence on how that child handles stress in adulthood.


Nonrhabdomyo-sarcoma STS, including synovial sarcoma, liposar-coma, malignant fibrous histiocytoma, and malignant peripheral nerve sheath tumors, account for the rest. Leukemias and lymphomas are also distributed differently in older adolescents than in young children. The incidence of acute lymphoblastic leukemia (ALL) declines steadily with age from the 0- to 5-year age group upwards it accounts for 30 of all cancers in children younger than 15 years, but only 6 of cancers in adolescents aged 15 to 19 years. Acute myelogenous leukemia (AML) is nearly as common as ALL in 15- to 19-year-olds, and is more common than ALL in 20- to 29-year-olds. The incidence of chronic myelogenous leukemia (CML) increases steadily with age from birth on, but it is not as common as either ALL or AML from 15 to 29 years of age. Juvenile myelomonocytic leukemia is uncommon in all four 5-year age groups before age 20 years, but especially in the 15- to 19-year age group....


The need for surgery that would necessitate general anesthesia became an issue in this patient who remained thyrotoxic after radioiodine therapy. Surgery and a variety of other stresses (infection, childbirth, trauma), are known to be precipitants of thyroid storm, although the risks are probably very low. Although several studies have shown that the outcomes after surgery in hypothyroid patients who are operated upon are no different


The hymen is the tissue that partially or completely surrounds the opening of the vagina. It appears that all females have hymenal tissue present at birth (91). The hymen may be annular (encircling the vaginal opening), cres-centic (present at the lateral and posterior margins), fimbriated (frilly edged), or, usually after childbirth, present only as interrupted tags or remnants. It is important that the reader refer to atlases that illustrate these variations (2,92). There is usually a single opening in the hymen. Uncommon congenital variants include two or more hymenal openings, referred to as septate or cribriform, respectively, and, rarely, complete absence of an opening (imperforate hymen).

Congenital Infection

The age of the patient at the time of sample collection for detection of CMV is of some importance. Neonates who acquire CMV during birth or from breast milk shed virus after 3 weeks of age. Thus, detection of CMV in urine or saliva after 3 weeks of age is not unequivocal proof of CMV acquisition in utero.


As the average human lifespan has increased, a concomitant increase in the incidence of deaths attributed to neurodegenerative disease has occurred.1 According to the National Vital Statistics Report of the US Centers for Disease Control, life expectancy from birth in 2003 was 77.6 years.1 This represents a 0.3-year increase from 2002, which was partially driven by increases in the number of deaths listed as due to AD, the eighth leading cause, and PD, the 14th leading cause. In comparison, the average life expectancy in 1900 was 47.3 years. Thus, with time, the pharmacoeconomic impact of neurodegenerative diseases on society is increasing. At the same time, new drug approvals have decreased, especially in the CNS area, suggesting that as technology has advanced, productivity has fallen. An interesting debate is ongoing that cancer may represent a risk factor in dementia,2 reflecting the yin and yang of cell death therapeutics. In cancer, the task is to enhance cell death, while in...

Thymic Architecture

In many ways, thymic pathology associated with HIV resembles the effects of aging on the thymus. In general, the thymus actively generates large numbers of T cells from birth until puberty, at which point thymic function declines throughout life. However, thymic involution begins as early as 1 year of age. During this process, the thymic epithelium folds in on itself and degenerates, as adipose tissue infiltrates the interlobular septa. Consequently, the thymus can no longer accommodate the numbers of thymocytes it once did, and T cell output declines. However, thymopoiesis continues at low levels well past the seventh decade of life.22 Given that children exhibit such robust thymic activity, HIV may have more severe effects on the young thymus than the aged thymus. In fact, HIV+ children showing signs of premature thymic atrophy have a poor prognosis and progress rapidly to AIDS.23

Maternal varicella

At any stage during pregnancy, chickenpox may cause intrauterine infection. Maternal varicella resulting in viremia may transmit the virus into the fetus by either transplacental spread, or by ascending infection from lesions in the birth canal (Birch et al., 2003). Furthermore, direct contact or respiratory droplet can lead to infection after birth. The consequences for the infant depend on the time of maternal disease. They range from asymptomatic infection to fetal loss especially in case of severe maternal disease. Pregnant women who contract varicella are at risk

Case Histories

During birth, Jane had a small hemorrhage into the part of the brain that controls the right side of her body. This left a scar that later became a small cyst. At age 14, she began to experience episodes of a warm feeling in her right hand. Several years later, while taking important school examinations, the warm feeling was followed by uncontrollable jerking and twitching of her right thumb and then her hand.


Primary intraocular tumour in children,with an incidence of one in 15,000 live births. It shows certain rather strange and unusual features. It is not usually present from birth, but occurs most frequently in infancy to age three years (although it can occur in older patients) it is either inherited as an autosomal dominant trait or can be sporadic in nature. Approximately 40 of cases are considered to be inherited. In one-third of inherited cases it appears in both eyes. A change in the RB1 gene on chromosome 13 is found in the inherited cases. Initially, it can be seen in an individual, suspected on account of the family history, as a small white, raised mass. Examination under anaesthesia is essential in such cases because the tumour might be in the extreme periphery of the fundus. A larger tumour can present as a white mass in the pupil (leucocoria) and such an appearance in infancy demands immediate referral to an ophthalmologist (Figure 15.2). Other presenting features include...

Simulation Test

We also generated random trees with different heights using Evolver in the PAML package We considered the trees with nine and sixteen leaves. The parameters used to generate the trees are 10 for Birth rate, 5 for Death rate, 1 for Sampling fraction, and 0.1, 0.2, 0.5, 1, 2, 5 for height. The height means the sum of the branch lengths from the root to all leaf nodes. For each possible conbination of parameter values, we generated one hundred random trees and estimated the transition probability along each branch using the Jukes-Cantor model. The left panel of Figure 4 shows the average unambiguous reconstruction accuracy for different heights. The right panel of Figure 4 shows the average ambiguous reconstruction accuracy for different heights. In both cases, the solutions output by our greedy algorithms are near optimal. Note also that, for ambiguous reconstruction accuracy, the backward greedy algorithm outperforms the forward greedy algorithm.

Heavy Metals

The developing fetus is very vulnerable to the toxic effects of mercury, lead, cadmium, and nickel, as well as industrial and agricultural chemicals. Small amounts of lead ingested by the mother in food and water can easily cross the placenta. Lead exposure of the fetus increases risk of premature birth. Moreover, the adverse effects of low-level lead exposure in utero can last long afterbirth - irreversibly impairing intellectual and motor development throughout childhood and lowering IQ.1. Exposure to mercury or polychlorinated biphe-nyls (widely used industrial chemicals) can retard fetal growth and cause birth defects.


The discoveries of the two BRCA genes gave birth to multiple testing systems in both the United States and Britain. While they varied widely, from a government-run national service that was part of preventive care to a laboratory technology marketed directly to consumers, each clearly incorporated into its technological architectures elements of toolkits that were specific to national context.

Diet Caries

Optimum nutrition during childhood can encourage formation of thick, acid-resistant enamel. The teeth gradually form and calcify from birth through the teen years, and a generous dietary supply of protein, calcium, fluoride, and vitamins C and D are important. Fluoride, incorporated into the enamel structure, sharply increases resistance of enamel to acid (see Fig. 5.3). Insufficient fluoride leaves teeth vulnerable to tooth decay. Low-level fluoride supplementation has great benefits adding trace amounts of fluoride to the water or salt supply can reduce risk of caries in children by more than two-thirds.9 However, too much can actually impair enamel formation and cause weakened, discolored teeth. In areas where water is fluoridated, supplementation with fluoride mouthwashes or tablets is unnecessary. However, in areas where the fluoride content of the water is very low or nonexistant, supplements are beneficial. The best time to give a fluoride supplement is at bedtime, after...

Effect Of Shear

Would be no production at all as the death rate would be very high than the birth rate. However, how much time the cell experiences such a shearing force would be also important. If the contact time is estimated from the size of the bubble and its rise velocity, for the cells to survive the contact time must be smaller than that the rise time of the bubble to cover distance equal to its own size. On the other hand, the relative velocity of at the interface must be much smaller than that estimated rise velocity of the bubble. The loss of viability of cells can be taken as a first-order process

Rhesus Rh Antigen

The major clinical significance of anti-Rh antibodies is related to hemolytic reactions associated with pregnancy that are similar to transfusion reactions. Rh-negative mothers carrying an Rh-positive fetus can be sensitized by fetal red blood cells that enter the maternal circulation, usually during childbirth. Since the Rh antigen is a protein, as opposed to the carbohydrate ABO antigens, class-switched IgG antibodies are generated in Rh-negative mothers. Subsequent pregnancies in which the fetus is Rh positive are at risk because the maternal anti-Rh antibodies can cross the placenta and mediate the destruction of the fetal red blood cells. This causes eryth-roblastosis fetalis (hemolytic disease of the newborn) and can be lethal for the fetus. This disease can be prevented by administration of anti-RhD antibodies to the mother within 72 hours of birth of the first Rh-positive baby. The treatment prevents the baby's Rh-positive red blood cells that entered the mother's circulation...

The Coalescent

Since the methods discussed in this chapter are based on genealogies of sequences, it is appropriate to describe the statistical properties of such genealogies. To do this, we must rely on Kingman's mathematical framework that describes the statistical distribution of times between coalescent events in a sample of sequences. This mathematical framework, the n-coalescent, or coalescent for short, allows one to model the expected time between coalescent events. Consider an ideal Wright-Fisher population of individuals that has remained constant at size N. From n of these individuals (where n is much smaller than N), a sample of sequences is obtained one from each individual. Several other assumptions need to be made. First, the sequences have evolved neutrally, or at least, if they are under selection, the intensity of selection is not strong enough to distort the timing of coalescent events. It is also assumed, for now, that the sequences have not recombined, and that the generations...

Mouse Phenotype

Another defect resulting from the mutant collagen became evident in the impaired reproductive ability of mutant females. In mammals, the uterine mass changes considerably during pregnancy and postpartum involution.40,41 In mice, the total uterine mass accounted for by collagen accumulation increases up to 20-fold during pregnancy, and after parturition the uterus rapidly recovers from prepregnant size.42 This postpartum involution is accomplished within the first two days after giving birth and involves transcriptional activation of the collagenase gene and increased release of collagenase extracellularly followed by the massive degradation of most of the collagen deposited in the uterus within a few days.40-42 In previously pregnant mutant r r females, degradation of collagen was severely disturbed, leading to the accumulation of nodules in the uterine wall. These nodules consisted of large collagen aggregates, reflecting the impaired collagen degradation during the postpartum period...

Informed Consent

At least four models of obtaining informed consent exist before labor, during labor, after collection, and phased.13 Before-labor consent allows the donor parent(s) to review and examine the consent documents weeks to months prior to childbirth. Donors not exposed to recruitment efforts, often as a result of inadequate prenatal care, may be excluded potential restriction in the diversity of the global UCB bank may result. During-labor consent occurs during the early phase of labor. Consent for testing and donation may also be obtained at this time. The after-collection model does not require consent for UCB collection. Once collected, an informed consent process for testing and donation is engaged. This may be troublesome given various personal, cultural, and religious beliefs toward UCB. In light of the potential advantages and disadvantages of these consent models, a phased consent policy has been adopted by some authorities. The premise upon which this policy is based is...

Age at first birth

Hill and Hurtado examined women's weight as a predictor of fertility. After controlling for age, and whether the previously born child was dead or alive, they found a significant contribution of body weight to predicting time to the next birth. Heavier women had children after a shorter interval than lighter women. Thus, delaying maturation to grow bigger yields greater fertility. Delaying too long cuts into the time available to reproduce, and lowers the probability of surviving from birth until reproduction begins. Fitting real-life parameters to equations summarising this trade-off predicts an optimal age and weight at first birth. The observed Ache age at first birth (17.5 years) fits well with the prediction, but the model predicts maturity at greater weight than observed. Hill and Hurtado then fit Kung weight and mortality data from Howell (1979) (but use the Ache regression of fertility on weight) to the equations and show that observed age at first birth fits the slightly...

Silk Making Goats

The company inserted the isolated spider gene into a goat's DNA at the embryo stage (an animal's earliest stage of development). The embryo was then transferred into the uterus (the female reproductive organ in which the baby animal develops before birth) of an adult female goat. When the genetically engineered goat matured and gave birth to its own young, the spider genes caused it to release spider silk proteins in its milk. Scientists were able to remove the liquid and isolate the spider silk protein. Then they pushed the protein through a tiny needle to form a silk thread like a spider would make.

Pregnancy And Childbirth

Pregnancy And Childbirth

If Pregnancy Is Something That Frightens You, It's Time To Convert Your Fear Into Joy. Ready To Give Birth To A Child? Is The New Status Hitting Your State Of Mind? Are You Still Scared To Undergo All The Pain That Your Best Friend Underwent Just A Few Days Back? Not Convinced With The Answers Given By The Experts?

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