Molecular cell biology courses now form a foundation for many subsequent specializations in areas outside cell biology. We therefore cover molecular genetics, metabolic pathways and electrophysiology in sufficient detail to make Cell Biology a suitable course book for first year students who will later specialize in genetics, biochemistry, pharmacology or physiology.
Each chapter comprises:
• The main text, with figures and tables.
' Review questions with answers for student self-assessment. These questions concern the main text only; no knowledge of the boxed material is required.
• Example boxes that illustrate the points made in the main text.
• Medical relevance boxes to show how basic cell biological knowledge illuminates medical problems or has provided solutions.
• In Depth boxes that extend the content.
Self-assessment questions can form the basics for tutorials, with students asked to defend the correct answer. They are also easily modified to generate new questions for student assessment. Instructors are encouraged to submit new questions for inclusion on the CBASC website.
Instructors may wish to specify parts of Cell Biology as core material for courses targeted to particular specialties. The parts chosen can be customized to the particular specialty in two ways:
1. By selecting from the complete set of twenty chapters. The following sections could be used to support particular teaching modules:
Chapters 4 through 7 Chapters 8 through 10 Chapters 11 through 13 Chapters 14 through 17 Chapter 18 Chapter 19
DNA, RNA and genetic engineering. Protein synthesis, structure and trafficking. Metabolism and cellular energetics. Electrophysiology and cell signaling. The cytoskeleton and cell motility. Cell division and apoptosis.
Chapters 16, 17 and 19 might in contrast be selected in a module concentrating on the control of development, since these describe how growth factors and other extracellular chemicals regulate cell division and cell death.
2. By including In Depth boxes. The following boxes are especially to be noted:
In Depth 9.1 In Depth 9.2 In Depth 9.3
In Depth 12.2 In Depth 12.3 In Depth 13.1 In Depth 13.2 In Depth 14.1 In Depth 14.2 In Depth 15.1 In Depth 16.1 In Depth 19.1 In Depth 20.1
How We Study Proteins in One Dimension describes SDS-PAGE Chirality and Amino Acids Hydropathy Plotting—The PDGF Receptor Curing Mad Mice with Smelly Fish introduces the concept of osmolarity and osmosis and extends the coverage of chaotropic and structure stabilizing agents What to Measure in an Enzyme Assay Determination of Vm and KM the Lineweaver-Burk plot ATP Synthase, Rotary Motor, and Synthetic Machine Can It Happen? The Concept of Free Energy The Urea Cycle—The First Metabolic Cycle Discovered The Glyoxylate Shunt The Nernst Equation Measuring the Transmembrane Voltage Frequency Coding in the Nervous System Ryanodine Receptors A Worm's Eye View of Cell Death Lipid Bilayer Voltage Clamp
For example, a course emphasizing protein structure would include In Depth 8.1, 9.1, 9.2 and 9.3, while a course concentrating on metabolic pathways would include In Depth 13.1 and 13.2.
The CBASC website is maintained by the authors. As well as providing over one hundred links to sites with information that extends or illustrates the material in the book, we will use the site to post typological or other errors, comments and test questions sent to us by readers. The full address is http://www.physiol.ucl.ac.uk/sbolsover/teaching/cbasc/cbasc.html or simply type 'CBASC' into a search engine.
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