Use Of Bnp For Risk Stratification In Heart Failure

BNP is a valuable marker for risk stratification in the setting of heart failure. In a study of 78 patients referred to a heart failure clinic, BNP showed a significant correlation to the heart failure survival score (38). In addition, changes in the plasma concentration of BNP were related to changes in the limitation of physical activities and were associated with the likelihood of deterioration in functional status. As such, BNP levels reflect New

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Fig. 9. Correlation of BNP with NYHA class. (Data from ref. 66.)

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Fig. 9. Correlation of BNP with NYHA class. (Data from ref. 66.)

Fig. 10. Risk of death or rehospitalization for heart failure stratified by BNP measured at time of visit to ED with dyspnea. (From ref. 39, with permission.)

York Heart Association (NYHA) functional classification (Fig. 9). Harrison et al. (39) followed 325 patients for 6 mo after an index visit to the ED for dyspnea. Higher levels of BNP were associated with a progressively worse prognosis (Fig. 10). The relative risk (RR) of 6-mo heart failure admission or death in patients with BNP levels >230 pg/mL was 24 times the risk for patients with lower levels.

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