Newborn infantspediatrics

cTnT and cTnI concentrations have been described in cord blood and for reference determinations in newborns and pediatric patients (64-67). In one study, 12 of 209 neo-nates showed increased cTnT levels at the time of delivery. Increases were associated with exposure to magnesium sulfate therapy by the mother prior to birth (68). It has been suggested that infants with respiratory distress at birth had increased cTnT levels (69). In a study of 18 infants, gestational age and birth weight influenced cTnI levels, with preterm infants having higher cTnl values (64). In older pediatric patients (up to 29 mo), cTnl values are generally not increased. However, in the context of severe, acute illness, increased cTnI values were indicators ofpoor outcomes, especially in cases in which cardiac contusion was suspected (70).

Fig. 10. Light microscopic evidence of damaged myocardial fibers and intracellular areas demonstrated by infiltrates of neutrophils, lymphocytes, and histiocytes (a) and vesicular nuclei-enlarged chromatin patterns of left ventricle from a rat subjected to 5 h of swimming (b). (Reproduced from

Change in Percent LVEF

Change in Percent LVEF

Month of

cTnl positive

cTnl negative

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