Lack ofAssay Standaridization

Owing to lack of assay standardization no generally applicable reference intervals for BNP can be defined at present. Currently, BNP reference and decision limits must be determined separately for each assay. Although assays for NT-proBNP are not yet standardized either, it is expected that the dependence of the most widely used assays on antibodies and calibrators from the same source will result in an acceptable agreement of reference ranges. In general, the concentrations of NT-proBNP are approx 20 times higher than those of BNP (12).

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