Platelets play a key role in the pathophysiology of cardiovascular disease (CVD). Disrupting platelet activation and aggregation with antiplatelet agents is effective for both primary and secondary prevention of atherothrombotic events and has become a cornerstone of CVD management nowadays (1). Originally, identifying the causes of abnormal bleeding and predicting normal hemostasis after surgery were the major goals of platelet function

From: Contemporary Cardiology: Cardiovascular Biomarkers: Pathophysiology and Disease Management Edited by: David A. Morrow © Humana Press Inc., Totowa, NJ

Fig. 1. Pathophysiology of platelet plug formation.

testing. In the modern era of cardiology, identifying hyperactive platelets as predictors of a thrombotic tendency and monitoring the response to antiplatelet agents have become the key objectives. The aim of this chapter is to provide an overview of platelet function monitoring in the clinical care of patients with CVD.

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