Frequency and Pathobiology of Troponin Elevation in Sepsis

Numerous reports have established that both cTnl and cTnT are biomarkers of myocardial injury in sepsis and septic shock or other systemic immune response syndromes (SIRSs), such as pancreatitis (27-32). Septic patients presenting to tertiary, urgent, and intensive care settings without documented heart disease have abnormal troponin results in a substantial proportion (31-85%) of cases. In a representative study among adult patients (n = 46) with septic shock, levels of cTnI (©0.4 Mg/L; Stratus II) and cTnT (>0.1 Mg/L; Elecsys 2010) were found to be elevated in 50 and 36%, respectively, with peak concentrations (median, interquartile range) of1.4 Mg/L (0.8-6.8 Mg/L) for cTnI and 0.66 Mg/L (0.19-1.51 ng/L) for cTnT (31).

The mechanism responsible for minor myocardial damage in this setting is not completely understood and a number of potential contributors should be considered. Certainly, elderly patients with sepsis are at risk of concomitant coronary atherosclerosis and may

Cumulative Survival

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