Clinical Considerations for Experimental Design

Certain features unique to cardiovascular conditions will influence the choice of proper experimental design. Whereas chronic conditions might lead to altered gene expression and changes in protein levels, acute insults will more likely induce rapid posttranslational modifications of preexisting proteins. The need to capture these modifications would also favor the use of certain analysis techniques. Similarly, the short time scale of evolution for acute cardiac conditions and the rapidity of proteome modulation must be considered, and both argue for multiple observations at specific time points.

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