Ca Inhibition As An Approach To Anticancer Therapy

Although there are no complete data that would link the phenotypic or therapeutic effects of CA inhibition as a means of tumor pH manipulation to perturbed activity of particular CA isozymes, the literature available so far clearly indicates that this is an exploitable avenue toward treating cancer. Teicher and co-workers 1993 showed that acetalozamide, a prototype carbonic anhydrase inhibitor CAI of several CA isozymes, reduced in vivo growth of tumors when given alone and produced additive...

CAIs In The Nervous System

CAIs have profound effects on the function of the CNS. For example, acetazolamide can reduce CSF production by ca. 50 Maren 1972 McCarthy and Reed 1974 . However, it has been known for long that acetazolamide dilates intracranial vessels Maren 1967 Hauge et al. 1983 . This vasodilatation increases cerebral blood volume CBV , which is considered to reflect an intrinsic, direct volume load to the intracranial cavity. In subjects with normal CSF circulation and absorption, the CBV increase does...

References

Abbate, F., Casini, A., Owa, T., Scozzafava, A., Supuran, C.T. 2004 Carbonic anhydrase inhibitors E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isoenzymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorganic and Medicinal Chemistry Letters 14, 217-223. Ashida, S., Nishimori, I., Tanimura, M., Onishi, S., and Shuin, T. 2002 Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell...