CAIs In Macular Edema Macular Degeneration And Related Ocular Pathologies

Optic nerve blood flow is diminished in the eyes of primary open-angle glaucoma suspects and patients (Pilts-Seymour et al. 2001). Because sulfonamides with CAI properties act as vasodilators (Supuran and Scozzafava 2000), this might explain the use of such drugs for treating retinal edema and age-related macular degeneration. In consequence, these pharmacological agents represent a new approach for improving visual function. Retinal edema (also referred to as cystoid macular edema) consists of...

Sulfonamides In The Treatment Of Glaucoma

Glaucoma is a chronic, degenerative eye disease, characterized by high IOP, which causes irreversible damage to the optic nerve head, and, as a result, the progressive loss of visual function and eventually blindness (Bartlett and Jaanus 1989 Maren 1992, 1995). Elevated IOP (ocular hypertension) is generally indicative of an early stage of the disease (Bartlett and Jaanus 1989 Soltau and Zimmerman 2002 Hoyng and Kitazawa 2002). CAIs represent the most physiological treatment of glaucoma,...

Ca Inhibition As An Approach To Anticancer Therapy

Although there are no complete data that would link the phenotypic or therapeutic effects of CA inhibition as a means of tumor pH manipulation to perturbed activity of particular CA isozymes, the literature available so far clearly indicates that this is an exploitable avenue toward treating cancer. Teicher and co-workers 1993 showed that acetalozamide, a prototype carbonic anhydrase inhibitor CAI of several CA isozymes, reduced in vivo growth of tumors when given alone and produced additive...

CAIs In The Nervous System

CAIs have profound effects on the function of the CNS. For example, acetazolamide can reduce CSF production by ca. 50 Maren 1972 McCarthy and Reed 1974 . However, it has been known for long that acetazolamide dilates intracranial vessels Maren 1967 Hauge et al. 1983 . This vasodilatation increases cerebral blood volume CBV , which is considered to reflect an intrinsic, direct volume load to the intracranial cavity. In subjects with normal CSF circulation and absorption, the CBV increase does...

References

Abbate, F., Casini, A., Owa, T., Scozzafava, A., Supuran, C.T. 2004 Carbonic anhydrase inhibitors E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isoenzymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorganic and Medicinal Chemistry Letters 14, 217-223. Ashida, S., Nishimori, I., Tanimura, M., Onishi, S., and Shuin, T. 2002 Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell...