Early studies demonstrated that elastoviscous hyaluronan solutions could influence granulation tissue formation, and scarring (8). These studies established a firm foundation for developing hyaluronan-based products for the control of postsurgi-cal adhesions, wound healing, and tissue engineering. The term matrix engineering was coined by one of the authors (E.A.B.) to describe the use of hyaluronan-based matrices to control, direct, or augment tissue regenerative processes (72,73). Ongoing efforts to bring this concept into clinical practice will be described in this section.
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