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To my wife Sunny and my children Natalie, Alex, and Megan, whose love and support make my work possible.

© 2003 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512

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Due diligence has been taken by the publishers, editors, and authors of this book to assure the accuracy of the information published and to describe generally accepted practices. The contributors herein have carefully checked to ensure that the drug selections and dosages set forth in this text are accurate and in accord with the standards accepted at the time of publication. Notwithstanding, as new research, changes in government regulations, and knowledge from clinical experience relating to drug therapy and drug reactions constantly occurs, the reader is advised to check the product information provided by the manufacturer of each drug for any change in dosages or for additional warnings and contraindications. This is of utmost importance when the recommended drug herein is a new or infrequently used drug. It is the responsibility of the treating physician to determine dosages and treatment strategies for individual patients. Further it is the responsibility of the health care provider to ascertain the Food and Drug Administration status of each drug or device used in their clinical practice. The publisher, editors, and authors are not responsible for errors or omissions or for any consequences from the application of the information presented in this book and make no warranty, express or implied, with respect to the contents in this publication.

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Cover illustration: Figure 4 from Chapter 12, "Combined Modality Therapy in Locally Advanced Breast Cancer," by Silvia C. Formenti and Matthew Volm.

Cover design by Patricia F. Cleary.

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Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $20.00 per copy is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [0-58829-028-X/03 $20.00].

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Library of Congress Cataloging-in-Publication Data

Chemoradiation in cancer therapy/edited by Hak Choy.

p. ; cm. — (Cancer drug discovery and development) ISBN 1-58829-028-X(alk. paper) 1-59259-325-9 (e-book)

1. Cancer—Adjuvant treatment. 2. Cancer—Chemotherapy. 3. Cancer—Radiotherapy. I. Choy, Hak. II. Series.

[DNLM: 1. Neoplasms—drug therapy. 2. Neoplasms--radiotherapy. 3. Combined Modality Therapy. QZ 266

C5174 2003]

RC271.A35 C445 2003 616.99'406--dc21

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