Contents

Part I. 1 Chemoradiation Biological Principles and Perspectives 3 2 Fluoropyrimidines as Radiation Muhammad Wasif Saif and Robert B. Diasio Part II. Mechanisms of Interaction of Specific Chemotherapeutic Agents with Radiation 45 3 The Role of Platinum Complexes in Combined Modality 4 Taxanes in Combined Modality 5 Camptothecin Radiation 6 The Role of Gemcitabine in Combined Modality Therapy 105 Jerome Landry, William Blackstock, Robert M. MacRae, Part III. Clinical 7 Chemoradiation Strategies...

Ns

CALGB, Cancer and Leukemia Group B EP, etoposide cisplatin LCSG, Lung Cancer Study Group PEF, cisplatin etoposide 5-fluorouracil PVF, cisplatin vinblastine 5-fluorouracil SWOG, Southwest Oncology Group Cbo E, carboplatin etoposide NS, not stated. CALGB, Cancer and Leukemia Group B EP, etoposide cisplatin LCSG, Lung Cancer Study Group PEF, cisplatin etoposide 5-fluorouracil PVF, cisplatin vinblastine 5-fluorouracil SWOG, Southwest Oncology Group Cbo E, carboplatin etoposide NS, not stated. less....

Concurrent Chemoradiation

The rationale for concurrent chemoradiation is that the ChT can augment local-regional control by both direct tumor cell killing and radiosensitization at the same time as it addresses systemic micrometastases. Unfortunately, this also has the potential to increase radiation-related mucosal acute toxicity, predominantly esophagitis and pneumonitis. Thus, some of the early trials of concurrent therapy used either attenuated dose ChT or split course RT to ameliorate potential cotoxicity. These...