John B. Mumm and Martin Oft
1 Introduction 26
2 The Inflammatory Trio: TNF-a, TGF-b, IL-6 28
3 The Local Trigger: IL-23 and IL-12 Balance in the Tumor Microenvironment 30
4 Feeding the Inflammatory Niche: Adaptive T Cell
Responses Fostering the Tumor 31
5 Turning Foes into Friends, CD8+ T Cells Lose Their Teeth 32
6 Inflammatory Control at the Tumor Site 33
7 Conclusions 35
Abstract Tumor immune surveillance and CD8+ T cells in particular appear capable of recognizing the antigenic properties of human tumor cells. However, those antigen specific T cells are often excluded from tumor tissue or are functionally limited in their cytotoxic capacity. Instead, the immune response provides proinflammatory cytokines and proteases promoting tumor growth and progression while subverting cytotoxic anti-tumor immunity. The cytokines and the inflammatory mechanisms driving tumor associated inflammation resemble tissue remodeling processes during wound healing and chronic inflammatory diseases. In this chapter, we summarize the current knowledge of how inflammatory cytokines may promote the deviation of anti-tumor immunity toward a tumor promoting, noncy-totoxic inflammation.
Merck Research Labs (formerly DNAX) 901 California Avenue, Palo Alto, CA 94303, USA e-mail: [email protected]
Current Topics in Microbiology and Immunology 344, DOI 10.1007/82_2010_47 © Springer-Verlag Berlin Heidelberg 2011, published online: 19 May 2010
Was this article helpful?
All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.