Electroencephalographs Studies of the Acute Effects of Psychoactive Drugs

It is relatively obvious that a critical reader should be mindful of the dose(s) of the drug administered in any given EEG study as well as whether the EEG data were collected before, during, or after the attainment of the peak blood level. An important but less obvious consideration in comparing findings across studies is whether the data were collected at-rest or during a task, or during eyes-closed versus eyes-open conditions. Other important methodological differences contributing to...

Jonathan M Levin MD MPH

Since the work of Roy and Sherrington at the end of the nineteenth century, the coupling of neural activity and cerebral blood flow (CBF) has been recognized as a fundamental principle of brain functional activity (Roy and Sherrington, 1890). For several decades, the radiotracer techniques have been mainstays in the effort to noninvasively image brain function. In the last two decades, computer-based advances in computational and data processing capacity have led to the development of...