In a study of 52 subjects with Parkinson's disease (PD) (28 men and 24 women), using DXA (Norland XR-26) to measure total body BMC, bone mineral content was found to be significantly decreased when compared to controls (78). The z-score for men with PD averaged -0.47 and for women, -0.84. In this same study, metacarpal radiogrammetry did not reveal any significant differences between PD patients and controls.
A brief report in abstract form from Turc et al. (79) noted that in 19 men with PD BMD in the PA spine as measured with DXA was significantly reduced in comparison to age-matched controls. BMD averaged 0.965 ± 0.146 g/cm2 in the PD subjects and 1.063 ± 0.146 g/cm2 in the controls. Although femoral bone density was also reduced in the PD subjects, the difference from age-matched controls was not significant.
Kao et al. (80) also measured PA spine bone density with DPA (M&SE OsteoTech 300, Medical and Scientific Enterprises, Sudbury, MA) in 22 PD subjects (3 women, 19 men) aged 58 to 76. All of the PD subjects had lower PA spine bone densities than healthy age-matched controls. Sixty-eight percent of the PD subjects had spine BMDs that were more than 2 SDs below the age-matched mean BMD.
Was this article helpful?