At Protein Level

Protein biomarkers and patterns of protein biomarkers may provide potential for diagnostics, intelligent drug design and intervention monitoring. One approach is to identify disease biomarkers upon quantification of a global pattern of proteins and peptides in serum or CSF of AD and controls. The most used techniques for protein profiling and identification of potential markers are 2-D gel electrophoresis and the protein chip arrays on which bound proteins are detected by a mass spectrometer...

Differential Diagnosis

The differential diagnosis of dementia is broad (DSM-IV, ICD10) and the diagnostic criteria keep evolving in order to improve sensitivity and specificity 2,118,119,120 . Subcortical dementia with prominent changes to the CSF analytical brain (striatum and thalamus) is distinguished from cortical dementias with prominent changes in the cortical association areas12. The spectrum of primary degenerative dementia includes AD, Down's syndrome, Pick's disease, primary progressive dysphasia, frontal...